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Ciclosporin therapy is associated with minimal changes in calcium metabolism in dogs with atopic dermatitis.
MedLine Citation:
PMID:  23140314     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background -  Ciclosporin is widely used in the management of canine atopic dermatitis. In humans, ciclosporin therapy has been linked to disturbances in calcium metabolism and resultant skeletal disorders. Objectives -  The objective of this study was to assess calcium homeostasis in dogs before and after a 6 week course of once daily oral ciclosporin at the licensed dose (5 mg/kg). Animals -  Sixteen client-owned dogs with spontaneous atopic dermatitis. Methods -  Serum concentrations of calcium, phosphate, creatinine, 25-hydroxyvitamin D, 1,25-dihyroxyvitamin D and plasma concentrations of ionized calcium and parathyroid hormone (PTH) were measured, together with the urinary fractional excretion of calcium and phosphate. The extent of skin lesions was scored using the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-03 and the degree of pruritus by the Edinburgh Pruritus Scale prior to and at the end of the study. Results -  The CADESI-03 and the Edinburgh Pruritus Scale scores decreased satisfactorily in all dogs by the end of the study. Plasma PTH concentrations were significantly increased (P = 0.02) following ciclosporin treatment, whereas all other biochemical parameters were not significantly different from their starting values. The increase in PTH was mild in most cases and the proportion of dogs that had a PTH concentration above the reference range was not significantly different following treatment. Conclusions and clinical importance -  This study indicates that ciclosporin has minimal impact on calcium metabolism in dogs with atopic dermatitis when used at the licensed and clinically effective dosage for 6 weeks.
Authors:
Marcel Kovalik; Richard J Mellanby; Helen Evans; Jacqueline Berry; Adri H M van den Broek; Keith L Thoday
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Veterinary dermatology     Volume:  23     ISSN:  1365-3164     ISO Abbreviation:  Vet. Dermatol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9426187     Medline TA:  Vet Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  481-e91     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Veterinary Dermatology © 2012 ESVD and ACVD.
Affiliation:
Dermatology Group, Division of Veterinary Clinical Sciences, Hospital for Small Animals, Easter Bush Veterinary Centre, The University of Edinburgh, Roslin, Midlothian EH25 9RG, UK Division of Veterinary Clinical Sciences, The Royal (Dick) School of Veterinary Studies, Hospital for Small Animals, Easter Bush Veterinary Centre, The Roslin Institute, Roslin, Midlothian EH25 9RG, UK Cambridge Specialist Laboratory Services, PO Box 967, Stapleford, Cambridge CB2 5XY, UK Vitamin D Research Group, Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK.
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