Document Detail

Ciclopirox nail lacquer for the treatment of onychomycosis: an open non-comparative study.
MedLine Citation:
PMID:  20175847     Owner:  NLM     Status:  MEDLINE    
Onychomycosis is a relatively common disease accounting for up to 50% of all nail disorders. Topical treatment, although less effective than systemic, is usually preferred by patients. Topical antifungal nail lacquers have been formulated to provide better delivery of the antifungal agent to the nail unit. The purpose of this research is to evaluate the efficacy and safety of ciclopirox nail lacquer in the treatment of onychomycosis. Patients suffering from distal and lateral subungual toenail onychomycosis (DLSO) and lateral subungual onychomycosis (LSO) were treated by ciclopirox nail lacquer once daily for 9 months. Every week the nail lacquer was removed using acetone. Clinical nail status, KOH examination and mycological culture were recorded by the same investigator at 0, 3, 6 and 9 months. Thirty-six patients completed the 9-month regimen. Trichophyton rubrum was the most common pathogen. At the end of the study, good improvement to complete cure was observed in 13 patients (36%), 12 patients showed only mild to moderate improvement and 11 patients (31%) had no clinical improvement. No adverse effects were noted throughout the treatment period. Ciclopirox nail lacquer seems to be slightly more effective than other topical modalities and could be used in patients who cannot or do not want systemic treatment.
Avner Shemer; Nir Nathansohn; Henri Trau; Boaz Amichai; Marcelo H Grunwald
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of dermatology     Volume:  37     ISSN:  1346-8138     ISO Abbreviation:  J. Dermatol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-23     Completed Date:  2010-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  137-9     Citation Subset:  IM    
Department of Dermatology, Sheba Medical Center, Tel-Hashomer, Israel.
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MeSH Terms
Administration, Topical
Antifungal Agents / administration & dosage*
Foot Dermatoses / drug therapy
Middle Aged
Onychomycosis / drug therapy*,  microbiology
Pyridones / administration & dosage*
Trichophyton / drug effects,  isolation & purification
Young Adult
Reg. No./Substance:
0/Antifungal Agents; 0/Pyridones; 29342-05-0/ciclopirox

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