Document Detail

Cicatricial pemphigoid with autoantibodies against the laminin 5 gamma 2 subunit.
MedLine Citation:
PMID:  15908306     Owner:  NLM     Status:  MEDLINE    
Cicatricial pemphigoid (CP) is an autoimmune bullous disease accompanied by mucosal lesions. The majority of patients with CP have autoantibodies against BP180. Anti-laminin 5 (epiligrin) CP is relatively rare. It is known that, in most cases, circulating autoantibodies against laminin 5 in these patients recognize the alpha3 and/or beta3 subunits of this molecule. Here we report a case of anti-laminin 5 CP, which showed IgG autoantibodies against the gamma2 subunit of laminin 5 alone. A 50-year-old woman suffered from skin blistering on the trunk and extremities and severe mucosal lesions in the eyes, oral cavities and laryngopharynx. Despite potent systemic steroids, the mucosal lesions and some parts of the skin lesions persisted. Salazosulfapyridine was of value in controlling the laryngopharyngeal lesions and persistent cutaneous blistering, and cyclophosphamide had definite effects especially on ocular lesions. Anti-laminin 5 autoantibodies became undetectable in serum from the patient after the disease was controlled.
Teruki Dainichi; Hiromichi Takeshita; Yoichi Moroi; Kazunori Urabe; Mariko Yoshida; Yoshiko Hisamatsu; Ayako Komai; Hong Duan; Tetsuya Koga; Takashi Hashimoto; Masutaka Furue
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of dermatology : EJD     Volume:  15     ISSN:  1167-1122     ISO Abbreviation:  Eur J Dermatol     Publication Date:    2005 May-Jun
Date Detail:
Created Date:  2005-05-23     Completed Date:  2005-08-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9206420     Medline TA:  Eur J Dermatol     Country:  France    
Other Details:
Languages:  eng     Pagination:  189-93     Citation Subset:  IM    
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Autoantibodies / drug effects*,  immunology*
Biopsy, Needle
Drug Therapy, Combination
Follow-Up Studies
Immunosuppressive Agents / therapeutic use
Laminin / pharmacology*
Middle Aged
Pemphigoid, Benign Mucous Membrane / drug therapy,  immunology*,  pathology*
Risk Assessment
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
0/Autoantibodies; 0/Immunosuppressive Agents; 0/Laminin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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