Document Detail


Cibenzoline for high-frequency ventricular arrhythmias: a short-term comparison with quinidine and a long-term follow-up.
MedLine Citation:
PMID:  3680585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cibenzoline, a new class I antiarrhythmic drug, was compared with quinidine in an open crossover study of 20 patients with frequent (greater than 30/hr) premature ventricular depolarizations (PVDs). Eight patients treated with cibenzoline experienced more than 75% reduction in PVD frequency. Cibenzoline completely suppressed ventricular couplets in eight of 17 patients and inhibited ventricular tachycardia (VT) in four of 13 patients. Only four patients (20%) responded to quinidine with a similar reduction in PVDs. Quinidine completely suppressed ventricular couplets in eight of 17 patients and episodes of VT in six of 13 patients. Cibenzoline prolonged PR, QRS, and QTc intervals. Eight patients who had shown more than a 75% reduction of PVDs were treated with cibenzoline for an extended period. At the end of three months, only five of eight patients continued to have 75% or greater reduction of PVDs. At the end of six and 12 months, four of five patients continued to have 75% or greater reduction of PVDs. Cibenzoline was similarly effective in suppressing complex arrhythmias. Thus, cibenzoline was only slightly superior to quinidine in suppressing ventricular arrhythmias. With long-term use of cibenzoline, significant PVD suppression was noted at the end of three months but not afterward.
Authors:
P R Palakurthy; C Maldonado; G Sohi; N C Flowers
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  27     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1988-01-11     Completed Date:  1988-01-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  283-7     Citation Subset:  IM    
Affiliation:
Division of Cardiology, University of Louisville School of Medicine, Kentucky 40292.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Anti-Arrhythmia Agents / adverse effects,  therapeutic use*
Arrhythmias, Cardiac / drug therapy*
Female
Follow-Up Studies
Humans
Imidazoles / adverse effects,  therapeutic use*
Male
Middle Aged
Quinidine / therapeutic use*
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Imidazoles; 53267-01-9/cifenline; 56-54-2/Quinidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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