| Cibenzoline attenuates coronary systolic reversal flow in a patient with hypertrophic obstructive cardiomyopathy: a case report. | |
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MedLine Citation:
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PMID: 17066624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of cibenzoline on coronary hemodynamics, especially systolic reversal flow, were assessed in a 53-year-old man with hypertrophic obstructive cardiomyopathy by coronary flow study using a Doppler guidewire. Intravenous administration of cibenzoline resulted in decreases in the pressure gradient (60 to 0mmHg) and systolic left ventricular pressure (162 to 126 mmHg), and an increase in systolic arterial pressure (102 to 132mmHg). Furthermore, the systolic reversal flow observed at baseline was markedly diminished following administration of cibenzoline. Therefore, we speculate that cibenzoline reduces ventricular wall stress by diminishing the left ventricular obstruction that occurs with compression of the intramyocardial arteries. Cibenzoline-induced attenuation of coronary systolic reversal flow may be associated with the effectiveness of cibenzoline for diminishing the left ventricular obstruction. |
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Authors:
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Keishi Saihara; Shuichi Hamasaki; Yutaka Otsuji; Takashi Yoshitama; Sanemasa Ishida; Tetsuro Kataoka; Hideki Okui; Chuwa Tei |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of cardiology Volume: 48 ISSN: 0914-5087 ISO Abbreviation: J Cardiol Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-10-27 Completed Date: 2006-11-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804703 Medline TA: J Cardiol Country: Japan |
Other Details:
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Languages: eng Pagination: 209-13 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Arrhythmia Agents
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pharmacology*,
therapeutic use Coronary Circulation / drug effects* Humans Imidazoles / pharmacology*, therapeutic use Male Middle Aged Ventricular Outflow Obstruction / drug therapy, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Imidazoles; 53267-01-9/cifenline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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