| Chymopapain chemonucleolysis in lumbar disk disease. | |
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MedLine Citation:
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PMID: 123015 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Experience with chymopapain chemonucleolysis in 1,200 cases of lumbar disk disease indicates that it is an effective method of relieving pain resulting from an abnormal intervertebral disk. Complications were few; anaphylaxis occurring immediately after injection was by far the most serious. With the use of a corticosteroid and an antihistamine in preoperative preparation, the incidence of anaphylaxis had dropped, although it still occurs. On long-term follow-up, chemonucleolysis appears to be as good as laminectomy in properly selected cases. |
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Authors:
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L L Wiltse; E R Widell; H A Yuan |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: JAMA : the journal of the American Medical Association Volume: 231 ISSN: 0098-7484 ISO Abbreviation: JAMA Publication Date: 1975 Feb |
Date Detail:
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Created Date: 1975-05-13 Completed Date: 1975-05-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7501160 Medline TA: JAMA Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 474-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anaphylaxis
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chemically induced Animals Back Pain / drug therapy Dogs Drug Evaluation Drug Evaluation, Preclinical Follow-Up Studies Humans Injections, Spinal Intervertebral Disk / drug effects*, radiography Intervertebral Disk Displacement / drug therapy*, radiography Myelography Peptide Hydrolases / administration & dosage, adverse effects, therapeutic use* Rabbits Sciatica / drug therapy Time Factors |
| Chemical | |
Reg. No./Substance:
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EC 3.4.-/Peptide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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