Document Detail


Chymase gene (CMA1) polymorphisms in Dutch and Japanese sarcoidosis patients.
MedLine Citation:
PMID:  16446531     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Chymase is released from mast cells following activation. Evidence suggests that chymase plays an important role in tissue injury and remodeling of the lungs, heart and skin. OBJECTIVE: We postulated that chymase gene (CMA1) polymorphisms are associated with pulmonary fibrosis in Dutch and with cardiac and skin involvement in Japanese sarcoidosis patients. PATIENTS AND METHODS: Dutch (n = 153) and Japanese (n = 122) sarcoidosis patients with controls (Dutch, n = 309; Japanese, n = 111) were studied. Pulmonary involvement in Dutch patients as well as clinical manifestations in Japanese patients was evaluated for association with five CMA1 polymorphisms. RESULTS: The CMA1 polymorphisms were not associated with disease susceptibility in either population, or with radiographic evolution in the Dutch or with cardiac or skin involvement in the Japanese patients. The -526 T allele was associated with a lower iVC in Dutch patients. CONCLUSIONS: The CMA1 polymorphisms studied do not contribute to disease susceptibility in Japanese or Dutch sarcoidosis patients. CMA1 polymorphisms do not influence radiographic evolution in Dutch sarcoidosis patients, nor do they predispose to cardiac or skin involvement in Japanese patients. However, the association between CMA1 -526 C/T and iVC in the Dutch patients suggests that chymase may modify the functional outcome of pulmonary sarcoidosis.
Authors:
Adrian Kruit; Jan C Grutters; Henk J T Ruven; Hiroe Sato; Takateru Izumi; Sonoko Nagai; Kenneth I Welsh; Roland M du Bois; Jules M M van den Bosch
Publication Detail:
Type:  Journal Article     Date:  2006-01-27
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  73     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  2006  
Date Detail:
Created Date:  2006-10-02     Completed Date:  2007-01-18     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  623-33     Citation Subset:  IM    
Affiliation:
Department of Pulmonology, Heart Lung Centre Utrecht, St. Antonius Hospital, Nieuwegein, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
3' Untranslated Regions / genetics
Adult
Aged
Asian Continental Ancestry Group / genetics*
Chymases / genetics*
European Continental Ancestry Group / genetics*
Female
Genetic Predisposition to Disease
Genotype
Haplotypes / genetics
Heart / physiology
Humans
Japan
Male
Middle Aged
Netherlands
Polymorphism, Single Nucleotide / genetics*
Promoter Regions, Genetic / genetics
Retrospective Studies
Sarcoidosis, Pulmonary / ethnology,  genetics*,  radiography
Skin / pathology
Chemical
Reg. No./Substance:
0/3' Untranslated Regions; EC 3.4.21.39/CMA1 protein, human; EC 3.4.21.39/Chymases

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