| Chylomicron remnants are increased in the postprandial state in CD36 deficiency. | |
| | |
MedLine Citation:
|
PMID: 18753675 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The clustering of risk factors including dyslipidemia, hyperglycemia, and hypertension is highly atherogenic along with the excess of remnants from triglyceride (TG)-rich lipoproteins. CD36 is involved in the uptake of long-chain fatty acids (LCFAs) in muscles and small intestines. Patients with CD36 deficiency (CD36-D) have postprandial hypertriglyceridemia, insulin resistance, and hypertension. To investigate the underlying mechanism of postprandial hypertriglyceridemia in CD36-D, we analyzed lipoprotein profiles of CD36-D patients and CD36-knockout (CD36-KO) mice after oral fat loading (OFL). In CD36-D patients, plasma triglycerides, apolipoprotein B-48 (apoB-48), free fatty acids (FFAs), and free glycerol levels were much higher after OFL than those of controls, along with increases in chylomicron (CM) remnants and small dense low-density lipoprotein (sdLDL) particles. In CD36-KO mice, lipoproteins smaller than CM in size in plasma and intestinal lymph were markedly increased after OFL and mRNA levels of genes involved in FFA biosynthesis, such as fatty acid binding protein (FABP)-1 and FAS, were significantly increased. These results suggest that CD36-D might increase atherosclerotic risk by enhancing plasma level of CM remnants due to the increased synthesis of lipoproteins smaller than CM in size in the intestine. |
| | |
Authors:
|
Daisaku Masuda; Ken-ichi Hirano; Hiroyuki Oku; Jose C Sandoval; Ryota Kawase; Miyako Yuasa-Kawase; Yasushi Yamashita; Masanori Takada; Kazumi Tsubakio-Yamamoto; Yoshihiro Tochino; Masahiro Koseki; Fumihiko Matsuura; Makoto Nishida; Toshiharu Kawamoto; Masato Ishigami; Masatsugu Hori; Iichiro Shimomura; Shizuya Yamashita |
Related Documents
:
|
8725165 - Lipid transfer from insect fat body to lipophorin: comparison between a mosquito triacy... 16740255 - A brief history of lipid and lipoprotein measurements and their contribution to clinica... 8433715 - Control of g1 to s cell cycle progression of trypanosoma brucei s427cl1 organisms under... 3435535 - Serum fatty acids analysis by high performance liquid chromatography, after enzymatic h... 9384725 - Orotic acid in clinical urine specimens by capillary zone electrophoresis using polyvin... 14577635 - Bioactive phenolics from carthamus lanatus l. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-27 |
Journal Detail:
|
Title: Journal of lipid research Volume: 50 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 2009 May |
Date Detail:
|
Created Date: 2009-04-08 Completed Date: 2009-07-07 Revised Date: 2010-09-21 |
Medline Journal Info:
|
Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: United States |
Other Details:
|
Languages: eng Pagination: 999-1011 Citation Subset: IM |
Affiliation:
|
Departments of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Animals Antigens, CD36 / deficiency*, genetics Chylomicrons / chemistry, metabolism* Dietary Fats Fasting Female Gene Expression Regulation Humans Intestinal Mucosa / chemistry, cytology, physiology Lipid Metabolism Lipoproteins / chemistry, metabolism Male Metabolic Syndrome X / metabolism Mice Mice, Inbred C57BL Mice, Knockout Middle Aged Particle Size Postprandial Period* |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD36; 0/Chylomicrons; 0/Dietary Fats; 0/Lipoproteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Blues from the neighborhood? Neighborhood characteristics and depression.
Next Document: Identification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol ...