Document Detail


Chylomicron remnants are increased in the postprandial state in CD36 deficiency.
MedLine Citation:
PMID:  18753675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The clustering of risk factors including dyslipidemia, hyperglycemia, and hypertension is highly atherogenic along with the excess of remnants from triglyceride (TG)-rich lipoproteins. CD36 is involved in the uptake of long-chain fatty acids (LCFAs) in muscles and small intestines. Patients with CD36 deficiency (CD36-D) have postprandial hypertriglyceridemia, insulin resistance, and hypertension. To investigate the underlying mechanism of postprandial hypertriglyceridemia in CD36-D, we analyzed lipoprotein profiles of CD36-D patients and CD36-knockout (CD36-KO) mice after oral fat loading (OFL). In CD36-D patients, plasma triglycerides, apolipoprotein B-48 (apoB-48), free fatty acids (FFAs), and free glycerol levels were much higher after OFL than those of controls, along with increases in chylomicron (CM) remnants and small dense low-density lipoprotein (sdLDL) particles. In CD36-KO mice, lipoproteins smaller than CM in size in plasma and intestinal lymph were markedly increased after OFL and mRNA levels of genes involved in FFA biosynthesis, such as fatty acid binding protein (FABP)-1 and FAS, were significantly increased. These results suggest that CD36-D might increase atherosclerotic risk by enhancing plasma level of CM remnants due to the increased synthesis of lipoproteins smaller than CM in size in the intestine.
Authors:
Daisaku Masuda; Ken-ichi Hirano; Hiroyuki Oku; Jose C Sandoval; Ryota Kawase; Miyako Yuasa-Kawase; Yasushi Yamashita; Masanori Takada; Kazumi Tsubakio-Yamamoto; Yoshihiro Tochino; Masahiro Koseki; Fumihiko Matsuura; Makoto Nishida; Toshiharu Kawamoto; Masato Ishigami; Masatsugu Hori; Iichiro Shimomura; Shizuya Yamashita
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-27
Journal Detail:
Title:  Journal of lipid research     Volume:  50     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-08     Completed Date:  2009-07-07     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  999-1011     Citation Subset:  IM    
Affiliation:
Departments of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Animals
Antigens, CD36 / deficiency*,  genetics
Chylomicrons / chemistry,  metabolism*
Dietary Fats
Fasting
Female
Gene Expression Regulation
Humans
Intestinal Mucosa / chemistry,  cytology,  physiology
Lipid Metabolism
Lipoproteins / chemistry,  metabolism
Male
Metabolic Syndrome X / metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Middle Aged
Particle Size
Postprandial Period*
Chemical
Reg. No./Substance:
0/Antigens, CD36; 0/Chylomicrons; 0/Dietary Fats; 0/Lipoproteins
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