Document Detail

Chylomicron metabolism in patients submitted to cardiac transplantation.
MedLine Citation:
PMID:  10708107     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Development of coronary graft disease is the most important cause of late heart graft failure. Alterations in plasma lipid profile are frequent in heart transplant (HT) patients, but they seem not to be prominent. Currently, the metabolism of chylomicrons, the lipoproteins that carry dietary lipids absorbed by the intestine, was evaluated because chylomicron remnants are considered atherogenic. METHODS: An emulsion labeled with 3H-triolein and 14C-cholesteryl oleate and known to mimic the metabolic behavior of chylomicrons was injected intravenously after a 12-hr fast into 34 HT patients, 24 patients with end-stage heart failure (ESHF), and 30 healthy normolipidemic subjects. The plasma disappearance curves of the radioisotopes were determined from blood samples collected over 1 hr. In some of the patients and in controls, in vitro postheparin lipolytic activity was measured and an oral fat load test with postprandial measurement of triglyceridemia was performed. RESULTS: Fractional clearance rate (in m(-1), median [25%; 75%]) of both emulsion 3H-triolein and 14C-cholesteryl oleate was extremely diminished in HT patients (HT: 0.0114 [0.0114; 0.0179] and 0.2x10(-8) [0.2x10(-8); 0.0041, respectively]; ESHF: 0.0226 [0.0223; 0.0568] and 0.0160 [0.0055; 0.0189]; control subjects: 0.0270 [0.0226; 0.0392] and 0.0090 [0.0042; 0.0180], respectively, P<0.05). HT patients also had reduced postheparin lipolysis and marked elevation of postprandial triglyceridemia compared with the controls. CONCLUSIONS: HT patients develop accumulation in the plasma of chylomicrons and their remnants. The observed alterations were so intense that they may suggest an important involvement of atherogenic chylomicron remnants in coronary graft disease.
C G Vinagre; N A Stolf; E Bocchi; R C Maranhão
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transplantation     Volume:  69     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-23     Completed Date:  2000-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  532-7     Citation Subset:  IM    
Heart Institute of the Faculty of Medicine Hospital (InCor-HCFMUSP), University of São Paulo, SP, Brazil.
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MeSH Terms
Apolipoproteins / metabolism
Body Mass Index
Cholesterol Esters / metabolism
Chylomicrons / metabolism*
Coronary Disease / etiology
Dietary Fats / pharmacology
Graft Rejection / etiology
Heart Transplantation / immunology,  physiology
Lipids / blood
Middle Aged
Triglycerides / blood
Reg. No./Substance:
0/Apolipoproteins; 0/Cholesterol Esters; 0/Chylomicrons; 0/Dietary Fats; 0/Emulsions; 0/Lipids; 0/Triglycerides

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