| Chuvash-type polycythemia in pregnancy managed by repeated venisections and heparin therapy: a case report. | |
| | |
MedLine Citation:
|
PMID: 18161409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Chuvash-type polycythemia is a rare blood disease associated with an increased tendency toward thrombosis and its resulting problems, which at times can be life threatening. The main goal of treatment is to prevent thrombosis and minimize the complications of therapy. CASE: A 20-year-old, Asian woman with her first pregnancy was admitted to the hospital at 16 weeks' gestation. Her initial blood work showed a hemoglobin level of 19 g/dL, hematocrit of 55% and erythropoietin level of 21.9 IU/L (laboratory reference range, 5-25). The results of a molecular analysis of the blood specimen confirmed the diagnosis of Chuvash-type polycythemia due to von Hippel-Lindau gene mutation. Weekly venisection until delivery was planned. Subsequently, the hemoglobin dropped to 15 g/dL and hematocrit to 44.6%. A 30-week scan demonstrated static growth below the third centile and oligohydramnios but normal Doppler findings. Prophylactic low-molecular-weight heparin was started. The next growth scan, at 32 weeks, showed an improvement in abdominal circumference. Three days later, fetal heart monitoring showed an abnormal pattern requiring an emergency cesarean section. CONCLUSION: Early institution of heparin is beneficial in the management of Chuvash-type polycythemia in pregnancy as the condition is thrombogenic. |
| | |
Authors:
|
Anjana Sinha; Deepali Sinha; Nalini Krishnamoorthy; Shagaf Bakour |
Related Documents
:
|
18617299 - Management of philadelphia negative chronic myeloproliferative disorders in pregnancy. 9325899 - Recurrent pregnancy loss: a review. 2340259 - Late symptoms after pregnancy-related deep vein thrombosis. 22309709 - Heavy metals and couple fecundity, the life study. 19474699 - Risk factors for clinical manifestations in carriers of factor v leiden and prothrombin... 22645279 - Birth weight following pregnancy during the 2003 southern california wildfires. 1236569 - Effect of gestational age and intrauterine nutrition on plasma transferrin and iron in ... 20655109 - Expression of liver x receptors in pregnancies complicated by preeclampsia. 12170149 - Hyrtl's fissure. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: The Journal of reproductive medicine Volume: 52 ISSN: 0024-7758 ISO Abbreviation: J Reprod Med Publication Date: 2007 Nov |
Date Detail:
|
Created Date: 2007-12-28 Completed Date: 2008-02-19 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0173343 Medline TA: J Reprod Med Country: United States |
Other Details:
|
Languages: eng Pagination: 1063-4 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, City Hospital, Birmingham, UK. kanhaiyakrishna@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Female Heparin, Low-Molecular-Weight / therapeutic use* Humans Infant, Newborn Point Mutation Polycythemia / genetics, therapy* Pregnancy Pregnancy Complications, Hematologic / genetics, therapy* Pregnancy Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Heparin, Low-Molecular-Weight |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Myocardial infarction in pregnancy associated with clomiphene citrate for ovulation induction: a cas...
Next Document: Vulvar metastasis as the initial presentation of non-Hodgkin's lymphoma: a case report.