Document Detail

Churg-Strauss syndrome with myocarditis manifesting as acute myocardial infarction with cardiogenic shock: case report and review of the literature.
MedLine Citation:
PMID:  14532945     Owner:  NLM     Status:  MEDLINE    
A patient with a two-year history of worsening asthma presented with chest pain and shortness of breath. She developed cardiogenic shock. Analysis of blood chemistry detected increased troponin I concentration. Her electrocardiographic changes were consistent with a diagnosis of anteroseptal myocardial infarction. However, angiography showed normal coronary arteries. Left ventriculography showed severe mitral regurgitation and global hypokinesis. Peripheral eosinophilia was detected. Subsequent endomyocardial biopsy showed myocarditis with prominent eosinophil and plasma cell components. Churg-Strauss syndrome was diagnosed based on her history of asthma, evidence of peripheral eosinophilia and results of endomycardial biopsy. Treatment with a high dose of corticosteroids was initiated. As symptoms of heart failure improved - without recurrence of cardiac and respiratory symptoms - the dose of corticosteroids was gradually reduced. Eight months after her original presentation, she developed urticarial lesions on her abdomen and legs, with muscle soreness but no other associated symptoms. She was treated with a combination of prednisone and dapsone. After the diagnosis of Churg-Strauss syndrome, the patient remained symptom free with a normal ejection fraction for 15 months while taking prednisone.
Miriam Shanks; Andrew P Ignaszewski; Sammy Y Chan; Michael F Allard
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  19     ISSN:  0828-282X     ISO Abbreviation:  Can J Cardiol     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-10-08     Completed Date:  2003-10-23     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1184-8     Citation Subset:  IM    
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MeSH Terms
Anti-Inflammatory Agents
Asthma / drug therapy,  epidemiology
Churg-Strauss Syndrome / complications*,  diagnosis*
Middle Aged
Myocardial Infarction / etiology*
Myocarditis / epidemiology*,  etiology*
Prednisone / therapeutic use
Shock, Cardiogenic / etiology*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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