| Churg-Strauss syndrome successfully treated with rituximab. | |
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MedLine Citation:
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PMID: 19789874 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Churg-Strauss syndrome (CSS) is characterized by small-vessel vasculitis, extravascular granulomatous inflammation, and massive eosinophilia in tissues and blood, and is often accompanied by a history of preclinical asthma and/or allergic rhinitis lasting several years before the syndrome develops its full clinical picture. Corticosteroids, often in combination with cytotoxic agents, comprise standard therapy; however, a number of patients appear to be resistant to treatment and there is a need for more effective regimens. B cell depletion may be an effective treatment option for CSS. Here, we describe two patients resistant to conventional therapy who were treated with rituximab and experienced a rapid and substantial decrease in disease activity and asthmatic symptoms and an increase in physical capacity. |
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Authors:
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Kristin Kveim Dønvik; Roald Omdal |
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Publication Detail:
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Type: Journal Article Date: 2009-09-30 |
Journal Detail:
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Title: Rheumatology international Volume: 31 ISSN: 1437-160X ISO Abbreviation: Rheumatol. Int. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-03-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: Germany |
Other Details:
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Languages: eng Pagination: 89-91 Citation Subset: IM |
Affiliation:
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Division of Internal Medicine, Department of Rehabilitation, Stavanger University Hospital, Stavanger, Norway. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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