Document Detail

Churg-Strauss syndrome presenting with focal segmental glomerulosclerosis without proteinuria: response to unconventional therapy.
MedLine Citation:
PMID:  23338924     Owner:  NLM     Status:  MEDLINE    
Churg-Strauss syndrome (CSS), or allergic granulomatosis, is a rare disease manifested by tissue infiltration, hypereosinophilia and vasculitis. Renal involvement may be seen in up to 50% of cases. We report the case of a 25-year old man who presented with a history of fever for two months, tingling, numbness, and paraesthesia of the upper limbs and left lower limb, along with diarrhoea for one month and an inability to walk for the past seven days. Serial laboratory investigations helped to reach the final diagnosis of CSS with mononeuritis multiplex, and skin, pulmonary and gastrointestinal involvement with hypertension. This is due to renal involvement in the form of focal segmental glomerulosclerosis without any nephrotic range proteinuria, which is a very rare clinical entity. The patient's symptoms were relieved after the administration of an unconventional mode of therapy.
Pradipta Guha; Indranil Thakur; Arindam Ray; Sanjoy Kumar Chatterjee
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Singapore medical journal     Volume:  54     ISSN:  0037-5675     ISO Abbreviation:  Singapore Med J     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-22     Completed Date:  2013-12-23     Revised Date:  2014-01-27    
Medline Journal Info:
Nlm Unique ID:  0404516     Medline TA:  Singapore Med J     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  e13-5     Citation Subset:  IM    
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MeSH Terms
Churg-Strauss Syndrome / complications*,  diagnosis*
Glomerulosclerosis, Focal Segmental / complications*,  diagnosis*
Kidney / pathology
Kidney Diseases / complications
Proteinuria / diagnosis
Radiography, Thoracic
Skin / pathology
Treatment Outcome

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