| Chronotropism and blood flow patterns following teratogenic doses of catecholamines in 5-day-old chick embryos. | |
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MedLine Citation:
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PMID: 22939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In vivo heart rates of 5-day-old chick embryos were recorded from electrodes placed in close proximity to the heart. L-epinephrine (4X10(-10) mole), 1-norepinephrine (1X10(-9)mole) and 1-isoproterenol (1.6X10(-10)mole) in 5 microliter of isotonic saline transiently accerlerated the mean heart rate by almost 9 percent. L-phenylephrine (2X10(-9)mole/5microliter) and the experimental procedure produced no appreciable effect. The positive chronotropic effect of the catecholamines was found to be highly significant (P less than 0.0005) as computed by Student's t test. However, no direct relationship could be established between the chronotropic response and the aortic arch anomalies produced. A prolonged reduction of blood flow in the primitive heart tube and the sixth aortic arch after administration of epinephrine and isoproterenol is apparently related to the induction of hypoplastic right pulmonary artery with absent or hypoplastic right ductus arteriosus. |
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Authors:
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M O Cheung; E F Gilbert; H J Bruyere; S Ishikawa; R J Hodach |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Teratology Volume: 16 ISSN: 0040-3709 ISO Abbreviation: Teratology Publication Date: 1977 Dec |
Date Detail:
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Created Date: 1978-02-18 Completed Date: 1978-02-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0153257 Medline TA: Teratology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 327-43 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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embryology* Adrenergic Agonists / pharmacology* Adrenergic beta-Agonists / pharmacology Animals Chick Embryo Heart / embryology* Heart Defects, Congenital / chemically induced* Heart Rate / drug effects* Phenylephrine / pharmacology Regional Blood Flow / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic Agonists; 0/Adrenergic beta-Agonists; 59-42-7/Phenylephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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