Document Detail

Chronotropism and blood flow patterns following teratogenic doses of catecholamines in 5-day-old chick embryos.
MedLine Citation:
PMID:  22939     Owner:  NLM     Status:  MEDLINE    
In vivo heart rates of 5-day-old chick embryos were recorded from electrodes placed in close proximity to the heart. L-epinephrine (4X10(-10) mole), 1-norepinephrine (1X10(-9)mole) and 1-isoproterenol (1.6X10(-10)mole) in 5 microliter of isotonic saline transiently accerlerated the mean heart rate by almost 9 percent. L-phenylephrine (2X10(-9)mole/5microliter) and the experimental procedure produced no appreciable effect. The positive chronotropic effect of the catecholamines was found to be highly significant (P less than 0.0005) as computed by Student's t test. However, no direct relationship could be established between the chronotropic response and the aortic arch anomalies produced. A prolonged reduction of blood flow in the primitive heart tube and the sixth aortic arch after administration of epinephrine and isoproterenol is apparently related to the induction of hypoplastic right pulmonary artery with absent or hypoplastic right ductus arteriosus.
M O Cheung; E F Gilbert; H J Bruyere; S Ishikawa; R J Hodach
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Teratology     Volume:  16     ISSN:  0040-3709     ISO Abbreviation:  Teratology     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-02-18     Completed Date:  1978-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0153257     Medline TA:  Teratology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  327-43     Citation Subset:  IM    
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MeSH Terms
Abnormalities, Drug-Induced / embryology*
Adrenergic Agonists / pharmacology*
Adrenergic beta-Agonists / pharmacology
Chick Embryo
Heart / embryology*
Heart Defects, Congenital / chemically induced*
Heart Rate / drug effects*
Phenylephrine / pharmacology
Regional Blood Flow / drug effects
Reg. No./Substance:
0/Adrenergic Agonists; 0/Adrenergic beta-Agonists; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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