| Chronotropic incompetence does not contribute to submaximal exercise limitation in patients with chronic heart failure. | |
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MedLine Citation:
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PMID: 18571253 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The traditional view of the origin of breathlessness and fatigue in patients with chronic heart failure (CHF) includes the concept that a contributing factor might be a limitation to increases in heart rate termed 'chronotropic incompetence' during exercise. In order to examine the relationship of heart rate on workload, we calculated the ratio of workload to heart rate for peak exercise and for steady state tests at 15%, 25% and 50% of peak in controls and CHF patients. The workload/heart rate ratio during the peak tests was lower in patients than control subjects. For each steady state test, patients had a lower absolute workload, and lower oxygen consumption than controls, but the same heart rate at steady state, leading to a lower workload/heart rate ratio in patients than controls. In addition, although we found a relationship between heart rate and workload for control subjects (r=0.85; p<0.0001), there was no such relationship in patients with chronic heart failure (r=0.003; p=0.98) during steady state exercise. Patients with CHF have a lower peak heart rate but a greater heart rate for a given workload during submaximal testing suggesting that heart rate limitation is unlikely to be the cause but rather the consequence of exercise intolerance in CHF patients. |
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Authors:
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Klaus K Witte; Andrew L Clark |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-06-20 |
Journal Detail:
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Title: International journal of cardiology Volume: 134 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-11 Completed Date: 2010-02-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 342-4 Citation Subset: IM |
Affiliation:
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Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, UK. klauswitte@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Chronic Disease Exercise / physiology* Exercise Test / methods* Heart Failure / diagnosis, physiopathology* Heart Rate / physiology* Humans Male Middle Aged |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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