| Chronopharmacological dependence of antihypertensive effects of the imidazoline-like drugs in stroke-prone spontaneously hypertensive rats. | |
| | |
MedLine Citation:
|
PMID: 9851566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In the present study we investigated the chronopharmacological dependence of dose-dependent hypotensive and cardiochronotropic effects of the imidazoline-like drugs (clonidine, rilmenidine and moxonidine) in stroke-prone spontaneously hypertensive rats (SHR-SP), using radio-telemetric system (Data Sciences, USA). The 24-h blood pressure, heart rate and locomotor activity profiles showed peak values during the rats' active phase during the night period. The degree of hypotensive and bradycardic effects of all drugs were most evident at this time and occurred in the absence of a change in locomotor activity. These studies show that clonidine, rilmenidine and moxonidine decrease blood pressure and heart rate in a time-dependent manner in SHR-SP. It was demonstrated that the degree and duration of hypotensive action of imidazoline-like drugs vary with the time of drug administration. |
| | |
Authors:
|
O S Medvedev; O R Kunduzova; A N Murashev; N A Medvedeva |
Related Documents
:
|
7406596 - Clonidine on the pressor response to raised intracranial pressure. 962436 - Effects of prostaglandins e1, e2 and f2 alpha and polyphloretin phosphate of domestic f... 6710216 - Hypertensive crisis in prazosin-treated pheochromocytoma. 21685736 - Beds: practical pressure management for surfaces/mattresses. 7897056 - Physiologic responses to loud tones in vietnam veterans with posttraumatic stress disor... 19444486 - Left ventricular mass in normotensive, prehypertensive and hypertensive children and ad... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of the autonomic nervous system Volume: 72 ISSN: 0165-1838 ISO Abbreviation: J. Auton. Nerv. Syst. Publication Date: 1998 Oct |
Date Detail:
|
Created Date: 1999-03-18 Completed Date: 1999-03-18 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8003419 Medline TA: J Auton Nerv Syst Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 170-6 Citation Subset: IM |
Affiliation:
|
Faculty of Basic Medicine, Department of Pharmacology, Moscow State University, Russian Federation. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antihypertensive Agents / pharmacology* Blood Pressure / drug effects Cerebrovascular Disorders / genetics, physiopathology* Circadian Rhythm* Clonidine / pharmacology Dose-Response Relationship, Drug Heart Rate / drug effects Hypertension / genetics, physiopathology* Imidazoles / pharmacology* Male Motor Activity / drug effects Oxazoles / pharmacology Rats Rats, Inbred SHR |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents; 0/Imidazoles; 0/Oxazoles; 4205-90-7/Clonidine; 54187-04-1/rilmenidine; 75438-57-2/moxonidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relationship between imidazoline and alpha2-adrenoceptors involved in the sympatho-inhibitory action...
Next Document: Effect of rilmenidine on the cadiovascular responses to stress in the conscious rabbit.