Document Detail


Chronopharmacokinetic study of a prolonged release form of indomethacin.
MedLine Citation:
PMID:  6873148     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The chronopharmacokinetics of indomethacin was studied in patients with rheumatoid diseases after a single oral dose of a new prolonged-release form containing indomethacin 75 mg. The drug was given either at 8, 12 or 20 h and its plasma concentrations, as well as those of its main metabolite, O-desmethyl indomethacin, were followed using a new specific gas chromatographic assay. When given at 20 h plasma indomethacin concentrations did not exhibit a sharp peak and remained much more stable than when the drug was given at 8 or 12 h. In addition, plasma O-desmethyl indomethacin was significantly higher after administration of indomethacin at 20 h than at 8 or 12 h. It is concluded that the pharmacokinetics of the oral prolonged-release form of indomethacin exhibited chronobiological variation. The data are in accordance with clinical studies which suggest that it might be worthwhile to administer this formulation of indomethacin at 20 h.
Authors:
P Guissou; G Cuisinaud; G Llorca; E Lejeune; J Sassard
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  24     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1983  
Date Detail:
Created Date:  1983-09-09     Completed Date:  1983-09-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  667-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Circadian Rhythm
Dealkylation
Delayed-Action Preparations
Female
Humans
Indomethacin / administration & dosage,  metabolism*
Kinetics
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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