Document Detail

Chrononutrition: use of dissociated day/night infant milk formulas to improve the development of the wake-sleep rhythms. Effects of tryptophan.
MedLine Citation:
PMID:  18019395     Owner:  NLM     Status:  MEDLINE    
Three different lactation experiments have been tested in a double blind procedure for 3 weeks, to improve sleep-wake patterns in infants. In a control experiment, standard infant commercial milk (1.5% tryptophan) was administered without changes during the day. In a second control (inverse), enriched milk (3.4% tryptophan) was given during light-time (06.00-18.00h), and standard commercial milk during night-time (18.00-06.00h). During the experimental week, the infants received standard milk during light-time and tryptophan enriched milk during night-time. The infants receiving the enriched formula during dark time showed improvements in the sleep parameters studied, and no statistical differences were found between the two control lactations. The urinary metabolites of serotonin suggest that the observed improvements were due to an increased use of serotonin to melatonin synthesis. In conclusion, the chronobiological changes in the normal components of the diet can improve infantile development of sleep/wake rhythms.
Sara Aparicio; Celia Garau; Susana Esteban; María C Nicolau; Montserrat Rivero; Rubén V Rial
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutritional neuroscience     Volume:  10     ISSN:  1028-415X     ISO Abbreviation:  Nutr Neurosci     Publication Date:    2007 Jun-Aug
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-01-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100892202     Medline TA:  Nutr Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  137-43     Citation Subset:  IM    
Institut Universitari de Ciències de la Salut, Universitat de les Illes Balears, Palma, Spain.
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MeSH Terms
Circadian Rhythm / drug effects,  physiology*
Infant Formula*
Infant Nutritional Physiological Phenomena*
Sleep / drug effects,  physiology*
Tryptophan / pharmacology*
Wakefulness / drug effects,  physiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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