Document Detail


Chronobiologic evolution of luteinizing hormone secretion in adolescence: developmental patterns and speculations on the onset of the polycystic ovary syndrome.
MedLine Citation:
PMID:  9130888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the long-term evolution of the LH circadian profile in adolescent women with anovulatory cycles and normal or elevated LH levels in the first evaluation. DESIGN: Prospective controlled clinical study. SETTING: Reproductive endocrinology unit of an academic medical center. PATIENT(S): Twelve healthy anovulatory adolescent girls aged 12 to 17 years (5 subjects with high plasma LH level and 7 subjects with normal LH level) and four ovulatory subjects as controls. INTERVENTION(S): Blood samples were drawn every 20 minutes for 24 hours beginning at 10:00 A.M. at early and late gynecologic ages. MAIN OUTCOME MEASURE(S): Luteinizing hormone, FSH, E2, T, androstenedione, ovarian volume. RESULT(S): In the first evaluation, the highest plasma LH levels and greatest pulse amplitude were found early in the morning in the normal-LH group and late in the afternoon in the high-LH group. Controls did not display any significant circadian variation in LH secretion. The second evaluation revealed ovulatory cycles in six of seven subjects (85.7%) in the normal-LH group with the disappearance of the circadian rhythm. Two of five (40%) patients with high LH in the first evaluation became ovulatory with a significant decrease of mean LH levels and the disappearance of the circadian rhythm. Girls of both groups who remained anovulatory still displayed the accentuated circadian profiles that were seen at the first evaluation. CONCLUSION(S): An accentuated 24-hour LH periodicity is typical of puberty but disappears in adulthood. The persistence of these rhythms in persistently anovulatory adolescents may indicate a maturational arrest. In particular, the persistence of the high LH circadian profile with the highest values during the day is very similar to that found in polycystic ovary syndrome.
Authors:
E Porcu; S Venturoli; M Longhi; R Fabbri; R Paradisi; C Flamigni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  67     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-05-15     Completed Date:  1997-05-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  842-8     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Bologna, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aging*
Androstenedione / blood
Child
Chronobiology Phenomena*
Circadian Rhythm
Estradiol / blood
Female
Follicle Stimulating Hormone / blood
Humans
Luteinizing Hormone / secretion*
Ovary / ultrasonography
Ovulation / physiology
Polycystic Ovary Syndrome / physiopathology*,  ultrasonography
Prospective Studies
Puberty / physiology*
Testosterone / blood
Chemical
Reg. No./Substance:
50-28-2/Estradiol; 58-22-0/Testosterone; 63-05-8/Androstenedione; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

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