| Chronic viral hepatitis. | |
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MedLine Citation:
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PMID: 11070570 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Both hepatitis B and hepatitis C are spread parenterally. Chronic hepatitis C is fast becoming the leading indication for liver transplantation. Most infected patients go on to develop chronic hepatitis, with approximately 20% developing liver cirrhosis or hepatocellular carcinoma after 20 years. Standard treatment now is with a combination of alpha-interferon and ribavirin, which is successful in up to 40% of patients. A vaccine is still a remote possibility and prevention remains all-important. Despite having a successful vaccine, chronic hepatitis B remains an important cause of liver cirrhosis and hepatocellular carcinoma. Treatments for active hepatitis include alpha-interferon and the newer nucleoside analogues such as lamivudine and adefovir. In patients undergoing liver transplantation, recurrence of hepatitis B in the graft can be reduced with a combination of hepatitis B immunoglobulin and these nucleoside analogues. |
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Authors:
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G Alexander; K Walsh |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: International journal of clinical practice Volume: 54 ISSN: 1368-5031 ISO Abbreviation: Int. J. Clin. Pract. Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2000-11-20 Completed Date: 2000-11-20 Revised Date: 2007-02-14 |
Medline Journal Info:
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Nlm Unique ID: 9712381 Medline TA: Int J Clin Pract Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 450-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, Addenbrooke's Hospital, Cambridge, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antiviral Agents
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therapeutic use Enzyme-Linked Immunosorbent Assay Hepatitis B, Chronic* / diagnosis, therapy, virology Hepatitis C, Chronic* / diagnosis, therapy, virology Hepatitis D, Chronic / diagnosis, therapy, virology Humans Interferon-alpha / therapeutic use Liver Transplantation / methods Polymerase Chain Reaction / methods |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Interferon-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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