Document Detail

Chronic villitis, chronic chorioamnionitis, and maternal floor infarction.
MedLine Citation:
PMID:  8210775     Owner:  NLM     Status:  MEDLINE    
Chronic inflammatory infiltrates in the human placenta are much less common than acute inflammation. Most often, chronic inflammation is found in the villi (villitis), but rarely it may involve the fetal membranes. Villitis is associated with many well-documented maternal infections. Reviewed herein are features of the villous inflammatory infiltrate and associated villous changes that may suggest a specific bacterial or protozoal etiology. However, the majority of villitides are of unknown etiology. These may be the result of an unrecognized pathogen or, alternatively, may reflect an abnormal immune reaction. Chronic chorioamnionitis is commonly associated with villitis and has accompanied some well-documented viral, bacterial, and protozoal infections, but a specific infectious etiology is not identified in many cases. Maternal floor infarction is not a true infarct; it is characterized by the deposition of fibrin in the decidua basalis and intervillous space where enveloped villi become avascular and sclerotic. Maternal floor infarction is associated with intrauterine growth retardation and fetal demise. It frequently recurs in successive pregnancies.
D J Gersell
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in diagnostic pathology     Volume:  10     ISSN:  0740-2570     ISO Abbreviation:  Semin Diagn Pathol     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-11-04     Completed Date:  1993-11-04     Revised Date:  2007-05-16    
Medline Journal Info:
Nlm Unique ID:  8502262     Medline TA:  Semin Diagn Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  251-66     Citation Subset:  IM    
Washington University School of Medicine, St Louis, MO 63110.
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MeSH Terms
Chorioamnionitis / pathology
Chorionic Villi / pathology*
Chronic Disease
Infarction / pathology*
Listeria Infections / pathology
Placenta Diseases / pathology*
Pregnancy Complications, Parasitic / pathology
Syphilis, Congenital / pathology
Toxoplasmosis / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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