Document Detail


Chronic ventricular tachyarrhythmias in the conscious dog: prevention by UM-272 (dimethylpropranolol).
MedLine Citation:
PMID:  6167806     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of chronic UM-272 (dimethylpropranolol) treatment to prevent the induction of reentrant ventricular tachyarrhythmias was assessed in the conscious dog subjected to serial programmed electrical stimulation on days 3--5 after myocardial infarction. In 20 untreated control animals, programmed electrical stimulation produced nonsustained ventricular tachycardia in 6 animals (30%), sustained ventricular tachycardia in 8 animals (40%), and ventricular fibrillation in 6 animals (30%) on the third day after occlusion and reperfusion of the left anterior descending coronary artery. On day 4, programmed electrical stimulation produced nonsustained ventricular tachycardia in 5 animals (36%), sustained ventricular tachycardia in 7 animals (50%), and ventricular fibrillation in 2 animals (14%). UM-272, 5 or 10 mg/kg, i.v., was administered every 12 hr to a separate group of 8 dogs after the induction of ischemic myocardial injury. Programmed electrical stimulation on day 3 after myocardial infarction failed to elicit ventricular arrhythmias in 4 animals (50%, p = 0.014), with acute administration of the next UM-272 dose preventing the induction of ventricular tachyarrhythmias in 7 animals (88%, p less than 0.0001). On day 4, programmed electrical stimulation failed to elicit ventricular arrhythmias in 5 aminals (63%, p = 0.0021). Thirty-six hours after the withdrawal of UM-272, programmed electrical stimulation produced ventricular fibrillation in 5 animals (63%) and sustained ventricular tachycardia which degenerated to ventricular fibrillation in 3 animals (37%). UM-272 significantly (p less than 0.05) depressed conduction in both normal and ischemically injured myocardium while also increasing (p less than 0.05) ventricular effective refractory periods. The results of these investigations suggest that UM-272 may be effective in preventing reentrant ventricular rhythms in hearts subjected to chronic myocardial ischemic damage and, therefore, may be of potential value in preventing reentrant ventricular arrhythmias in man.
Authors:
E Patterson; B R Lucchesi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  3     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:    1981 Jul-Aug
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  769-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chronic Disease
Dogs
Electric Stimulation
Heart Conduction System / drug effects
Heart Ventricles
Male
Myocardial Infarction / complications
Propranolol / analogs & derivatives*,  therapeutic use
Tachycardia / etiology,  prevention & control*
Time Factors
Ventricular Fibrillation / prevention & control
Grant Support
ID/Acronym/Agency:
HL-05806-21/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
50643-33-9/pranolium; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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