Document Detail

Chronic vagus nerve stimulation improves left ventricular function in a canine model of chronic mitral regurgitation.
MedLine Citation:
PMID:  25366939     Owner:  NLM     Status:  Publisher    
BackgroundAutonomic dysfunction, characterized by sympathetic activation and vagal withdrawal, contributes to the progression of heart failure (HF). We hypothesized that chronic vagus nerve stimulation (VNS) could prevent left ventricular (LV) remodeling and dysfunction in a canine HF model induced by chronic mitral regurgitation (MR).Methods and resultsAfter the MR inducing procedure, 12 survived canines were randomly divided into the control (n¿=¿6) and the VNS (n¿=¿6) groups. At month 2, a VNS stimulator system was implanted in all canines. From month 3 to month 6, VNS therapy was applied in the VNS group but not in the control group. At month 6, compared with the control group, the canines in VNS group had significantly higher cardiac output (2.3¿±¿0.3 versus 2.9¿±¿0.4 L/min, P¿<¿0.05 , LV forward stroke volume (20.1¿±¿3.7 versus 24.8¿±¿3.9 ml, P¿<¿0.05), and end-systolic stiffness constant (2.2¿±¿0.3 versus 2.7¿±¿0.3, P¿<¿0.05). NT-proBNP and C-reactive protein were decreased significantly in the VNS group. However, no statistical difference was found in LV ejection fraction, LV end-diastolic dimension, LV end-diastolic volume, myocyte cross-sectional area, or collagen volume fraction between two groups.ConclusionsChronic VNS therapy may ameliorate MR-induced LV contractile dysfunction and improve the expression of biomarkers, but has less effect in improving LV chamber remodeling.
Haiwen Yu; Min Tang; Jun Yu; Xiaohong Zhou; Lepeng Zeng; Shu Zhang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-4
Journal Detail:
Title:  Journal of translational medicine     Volume:  12     ISSN:  1479-5876     ISO Abbreviation:  J Transl Med     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-4     Completed Date:  -     Revised Date:  2014-11-5    
Medline Journal Info:
Nlm Unique ID:  101190741     Medline TA:  J Transl Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  302     Citation Subset:  -    
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