Document Detail

Chronic unpredictable stress decreases cell proliferation in the cerebral cortex of the adult rat.
MedLine Citation:
PMID:  17585885     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: One of the most consistent morphologic findings in postmortem studies of brain tissue from depressed patients is a decrease in the number of glia in the prefrontal cortex. However, little is known about the mechanisms that contribute to this decrease in cell number. METHODS: To address this question, we subjected adult rats to chronic stress, a vulnerability factor for depression, and measured cell proliferation as a potential cellular mechanism that could underlie glial reduction in depression. RESULTS: We found that exposure to chronic unpredictable stress (CUS) for 15 days significantly decreased cell proliferation in neocortex by approximately 35%. This effect was dependent on the duration, intensity and type of stress, and was region-specific. Analysis of cell phenotype demonstrated that there was a decrease in the number of oligodendrocytes and endothelial cells. Finally, using a CUS paradigm that allows for analysis of anhedonia, we found that chronic antidepressant administration reversed the decrease in cortical cell proliferation, as well as the deficit in sucrose preference. CONCLUSION: These findings are consistent with the possibility that decreased cell proliferation could contribute to reductions in glia in prefrontal cortex of depressed subjects and further elucidate the cellular actions of stress and antidepressants.
Mounira Banasr; Gerald W Valentine; Xiao-Yuan Li; Shannon L Gourley; Jane R Taylor; Ronald S Duman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-06-21
Journal Detail:
Title:  Biological psychiatry     Volume:  62     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-27     Completed Date:  2007-10-26     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  496-504     Citation Subset:  IM    
Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
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MeSH Terms
Analysis of Variance
Antidepressive Agents, Second-Generation / pharmacology,  therapeutic use
Behavior, Animal
Bromodeoxyuridine / metabolism
Cell Proliferation* / drug effects
Cerebral Cortex / drug effects,  pathology*
Conditioning, Operant / drug effects,  physiology
Corticosterone / pharmacology
Disease Models, Animal
Fluoxetine / pharmacology,  therapeutic use
Ki-67 Antigen / metabolism
Neuroglia / metabolism,  pathology
Neurons / metabolism,  pathology*
Rats, Sprague-Dawley
Stress, Psychological / drug therapy,  pathology*,  physiopathology*
Grant Support
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 0/Ki-67 Antigen; 50-22-6/Corticosterone; 54910-89-3/Fluoxetine; 59-14-3/Bromodeoxyuridine

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