Document Detail


Chronic unpredictable mild stress affects myocardial metabolic profiling of SD rats.
MedLine Citation:
PMID:  22658902     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Depression is frequently comorbid with cardiovascular diseases (CVDs), but a full understanding of the mechanisms is still on its way. Chronic unpredictable mild stress (CUMS) model is a commonly used model to mimic clinical depression, here we present a GC/MS-based metabolic profiling approach to investigate myocardial metabolic changes of CUMS SD rats. Principal Component Analysis (PCA) and Partial Least Squares-Discriminant Analysis (PLS-DA) were utilized to reveal differences between the model and control group. This study found that molecules proved cardioprotective involving glutamine (P=0.019) and inosine (P=0.013), fatty acid (9,12-octadecadienoic acid, P=0.002; hexadecanoic acid, P=0.006; octadecanoic acid, P=0.030) which serve as the major energy source of heart and collagen molecule precursor proline (P=0.036) had down-regulated in CUMS model group.
Authors:
Wen-Yuan Zhang; Shao Liu; Huan-de Li; Hua-Lin Cai
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-10
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  -     ISSN:  1873-264X     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-6-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Clinical Pharmaceutical Research Institute, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China.
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