| Chronic unpredictable mild stress affects myocardial metabolic profiling of SD rats. | |
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MedLine Citation:
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PMID: 22658902 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Depression is frequently comorbid with cardiovascular diseases (CVDs), but a full understanding of the mechanisms is still on its way. Chronic unpredictable mild stress (CUMS) model is a commonly used model to mimic clinical depression, here we present a GC/MS-based metabolic profiling approach to investigate myocardial metabolic changes of CUMS SD rats. Principal Component Analysis (PCA) and Partial Least Squares-Discriminant Analysis (PLS-DA) were utilized to reveal differences between the model and control group. This study found that molecules proved cardioprotective involving glutamine (P=0.019) and inosine (P=0.013), fatty acid (9,12-octadecadienoic acid, P=0.002; hexadecanoic acid, P=0.006; octadecanoic acid, P=0.030) which serve as the major energy source of heart and collagen molecule precursor proline (P=0.036) had down-regulated in CUMS model group. |
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Authors:
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Wen-Yuan Zhang; Shao Liu; Huan-de Li; Hua-Lin Cai |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-10 |
Journal Detail:
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Title: Journal of pharmaceutical and biomedical analysis Volume: - ISSN: 1873-264X ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-6-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309336 Medline TA: J Pharm Biomed Anal Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier B.V. All rights reserved. |
Affiliation:
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Clinical Pharmaceutical Research Institute, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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