Document Detail


Chronic ulcerative stomatitis: evidence of autoimmune pathogenesis.
MedLine Citation:
PMID:  21459019     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: Chronic ulcerative stomatitis is a condition characterized by chronic, painful oral ulcers, whose pathogenesis is unknown. Patients demonstrate specific IgG autoantibodies against ΔNp63α, an epithelial nuclear transcription factor. The aim of this study was to investigate the role of patient autoantibodies in the disease pathogenesis. METHODS: Three-dimensional in vitro tissues consisting of a fully differentiated, multilayer epithelium that mimics its in vivo counterpart were incubated with serum from patients with chronic ulcerative stomatitis. RESULTS: Our results show a subepithelial detachment of the epithelium at the basement membrane interface, mimicking the oral ulcerations that are seen clinically. Expression of basement membrane proteins Type IV collagen and laminin-5 was unaltered, whereas the expression of α6β4 integrins, hemidesmosome components that attach basal keratinocytes to the basement membrane, was reduced, as determined by immunohistochemistry. CONCLUSION: These results give evidence that patient autoantibodies are pathogenic; and support an autoimmune pathogenesis in chronic ulcerative stomatitis.
Authors:
Mark W Carlson; Jonathan A Garlick; Lynn W Solomon
Related Documents :
10773149 - The significance of sinistral portal hypertension complicating chronic pancreatitis.
7375969 - Peer review in diabetes and hypertension: the relationship between care process and pat...
3963979 - Minoxidil, nadolol, and a diuretic. once-a-day therapy for resistant hypertension.
2142489 - Improved results with surgical treatment of renovascular hypertension: an individualize...
10386279 - Renin-aldosterone system and atrial natriuretic peptide during anesthesia in orthopedic...
7022849 - A prospective study of methylprednisolone and prednisone as immunosuppressive agents in...
16402089 - Nephrostomies in obstructive uropathy; how should hormone resistant prostate cancer pat...
24092849 - Echocardiographical determinants of an abnormal spatial qrs-t angle in chronic dialysis...
18086309 - Health-related quality of life and long-term prognosis in chronic hypercapnic respirato...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-31
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  -     ISSN:  1528-395X     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-4-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Mosby, Inc. All rights reserved.
Affiliation:
Research Administration, School of Dental Medicine, Tufts University, Boston, MA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Establishment of a stable CHO cell line with high level expression of recombinant porcine IFN-?
Next Document:  Review of metastasizing (malignant) ameloblastoma (METAM): Pattern of metastasis and treatment.