Document Detail

Chronic ulcerative stomatitis: diagnostic and management challenges--four new cases and review of literature.
MedLine Citation:
PMID:  17560144     Owner:  NLM     Status:  MEDLINE    
Chronic ulcerative stomatitis (CUS) is a recently described mucocutaneous disease characterized by involvement of mucosal surfaces and skin. The disease usually presents in the form of painful oral ulcers and has been seen predominantly among older women. Clinically, CUS patients may exhibit erosive or ulcerative lesions of oral mucosa resembling erosive lichen planus and/or other vesiculobullous lesions. Routine histology may exhibit features of lichenoid mucositis and is often nondiagnostic. Direct immunofluorescence studies of mucosal or skin biopsies usually reveal a unique pattern of IgG bound to nuclei of keratinocytes of the basal and parabasal cell layers. Chronic ulcerative stomatitis exhibits a unique resistance to standard treatments available, including topical and systemic corticosteroids and immunomodulatory medications. However, long-lasting favorable clinical responses may be achieved with hydroxychloroquine pharmacotherapy. We present the clinicoimmunopathologic findings of four cases of CUS and discuss the varied clinical, microscopic spectrum, and treatment for this chronic, debilitating, and often recalcitrant condition. A systematic review of the literature, including 35 previously reported cases, is presented.
M N Islam; D M Cohen; J Ojha; C M Stewart; J Katz; I Bhattacharyya
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2007-06-07
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  104     ISSN:  1528-395X     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-16     Completed Date:  2007-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  194-203     Citation Subset:  D; IM    
Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, University of Florida, Gainesville, FL 32610, USA.
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MeSH Terms
Aged, 80 and over
Chronic Disease
Dermatologic Agents / therapeutic use*
Fluorescent Antibody Technique, Direct
Hydroxychloroquine / therapeutic use*
Immunosuppressive Agents / therapeutic use
Oral Ulcer / drug therapy,  pathology*
Stomatitis / drug therapy,  pathology*
Reg. No./Substance:
0/Dermatologic Agents; 0/Immunosuppressive Agents; 118-42-3/Hydroxychloroquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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