| Chronic treatment with imipramine inhibits cell growth and enhances serotonin 2C receptor mRNA expression in NG 108-15 cells. | |
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MedLine Citation:
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PMID: 12939530 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We previously reported that NG108-15 cells contain intrinsic serotonin 2C receptor (5-HT2CR). The effects of imipramine, a 5-HT2CR antagonist, on cell growth, cell viability, and the 5-HT2CR mRNA level were investigated in this study. Repeated treatment with imipramine at concentrations of 1 - 10 microM for 5 days inhibited cell growth in a concentration-dependent manner without affecting cell viability. In addition, the level of 5-HT2CR mRNA was elevated. At 30 microM, imipramine significantly reduced cell viability. Our findings suggest that the effect of imipramine on neuronal growth may be related to its effects on 5-HT2CR. |
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Authors:
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Monrudee Sukma; Michihisa Tohda; Hiroshi Watanabe |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmacological sciences Volume: 92 ISSN: 1347-8613 ISO Abbreviation: J. Pharmacol. Sci. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-08-26 Completed Date: 2004-05-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101167001 Medline TA: J Pharmacol Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 433-6 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Division / drug effects, physiology Cell Line, Tumor Cell Survival / drug effects, physiology Dose-Response Relationship, Drug Gene Expression Regulation / drug effects*, physiology Imipramine / administration & dosage* RNA, Messenger / biosynthesis*, genetics Rats Receptor, Serotonin, 5-HT2C / biosynthesis*, genetics |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 0/Receptor, Serotonin, 5-HT2C; 50-49-7/Imipramine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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