Document Detail

Chronic treatment with both lithium and sodium valproate may normalize phosphoinositol cycle activity in bipolar patients.
MedLine Citation:
PMID:  12415549     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It has been proposed that lithium may be clinically effective due to its actions on the phosphoinositol second messenger system (PI-cycle). Studies have also suggested that untreated manic patients may have raised myo-inositol and phosphomonoester (PME) concentrations and also that unmedicated euthymic bipolar patients may have lowered PME concentrations. The objective of the present study was to test the hypothesis that chronic treatment with either lithium or sodium valproate in patients with bipolar mood disorder leads to a normalization in the activity of the PI-cycle. METHODS: This study had two parts each with different MRS methodology. The first part compared healthy controls (n = 19) with euthymic bipolar patients who were taking either lithium (n = 16) or sodium valproate (n = 11) using both (1)H-MRS and (31)P-MRS. In the second part we examined a separate group of euthymic bipolar disorder patients taking sodium valproate (n = 9) and compared these with age and sex-matched healthy controls (n = 11) using (1)H-MRS. RESULTS: Both studies showed that there were no differences in either myo-inositol or phosphomonoester (PME) concentrations between controls and patients taking either medication. CONCLUSIONS: These findings examine two key components of the PI-cycle in treated euthymic bipolar (myo-inositol and PME concentrations). The results from this study are consistent with the suggestion that chronic treatment with either lithium or sodium valproate in bipolar patients may normalize PI-cycle functioning.
Peter H Silverstone; Ren H Wu; Tina O'Donnell; Michele Ulrich; Sheila J Asghar; Christopher C Hanstock
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Human psychopharmacology     Volume:  17     ISSN:  0885-6222     ISO Abbreviation:  Hum Psychopharmacol     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-11-04     Completed Date:  2002-11-19     Revised Date:  2008-03-06    
Medline Journal Info:
Nlm Unique ID:  8702539     Medline TA:  Hum Psychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  321-7     Citation Subset:  IM    
Copyright Information:
Copyright 2002 John Wiley & Sons, Ltd.
Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada.
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MeSH Terms
Antimanic Agents / therapeutic use*
Bipolar Disorder / drug therapy*,  metabolism
Brain Chemistry / drug effects
Frontal Lobe / drug effects,  metabolism
Inositol / metabolism
Lithium / therapeutic use*
Magnetic Resonance Spectroscopy
Phosphatidylinositols / metabolism*
Psychiatric Status Rating Scales
Temporal Lobe / drug effects,  metabolism
Valproic Acid / therapeutic use*
Reg. No./Substance:
0/Antimanic Agents; 0/Phosphatidylinositols; 6917-35-7/Inositol; 7439-93-2/Lithium; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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