| Chronic treatment with the D1 receptor antagonist, SCH 23390, and the D2 receptor antagonist, raclopride, in cebus monkeys withdrawn from previous haloperidol treatment. Extrapyramidal syndromes and dopaminergic supersensitivity. | |
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MedLine Citation:
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PMID: 7871047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of chronic treatment with dopamine (DA) D1 and D2 receptor antagonists were evaluated in eight cebus apella monkeys with mild oral dyskinesia after previous haloperidol treatment. SCH 23390 (D1 antagonist) was given daily to investigate the direct behavioural effect during long-term treatment and the subsequent supersensitivity to DA agonists. Raclopride (D2 antagonist) was investigated for comparison. All drugs were given subcutaneously. SCH 23390 and raclopride induced dystonic syndromes, catalepsy, sedation and reduced locomotor activity. The monkeys developed marked tolerance to the dystonic effect of SCH 23390, while they showed increased sensibility to the dystonic effect of raclopride. Baseline oral dyskinesia (24 h after injection) remained unchanged during D1 antagonist treatment, while it increased during D2 antagonist treatment. SCH 23390 induced supersensitivity to the oral dyskinesia- and grooming-inducing effects of SKF 81297 (D1 agonist) after 9 weeks, while the subsequent treatment with raclopride induced supersensitivity to the reactivity- and stereotypy-inducing effects of quinpirole (D2 receptor agonist) after 3 weeks. Because of the possibility of a carry-over effect (SKF 81297-induced oral hyperkinesia and grooming), other changes in raclopride-induced behaviours cannot be ruled out. The development of tolerance to the dystonic effect of SCH 23390 and the unchanged baseline oral dyskinesia during SCH 23390 treatment indicate an advantageous profile of side effects of DA D1 receptor blockade. |
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Authors:
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H Lublin; J Gerlach; L Peacock |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Psychopharmacology Volume: 112 ISSN: 0033-3158 ISO Abbreviation: Psychopharmacology (Berl.) Publication Date: 1993 |
Date Detail:
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Created Date: 1995-03-30 Completed Date: 1995-03-30 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7608025 Medline TA: Psychopharmacology (Berl) Country: GERMANY |
Other Details:
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Languages: eng Pagination: 389-97 Citation Subset: IM |
Affiliation:
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St Hans Hospital, Department P, Roskilde, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Basal Ganglia Diseases / chemically induced, physiopathology Behavior, Animal / drug effects* Benzazepines / pharmacology* Cebus Dopamine / physiology Dose-Response Relationship, Drug Female Grooming / drug effects Haloperidol / adverse effects* Hypnotics and Sedatives / pharmacology Male Motor Activity / drug effects Raclopride Receptors, Dopamine D1 / agonists, antagonists & inhibitors* Receptors, Dopamine D2 / agonists, antagonists & inhibitors* Salicylamides / pharmacology* Stereotyped Behavior / drug effects Substance Withdrawal Syndrome / psychology* |
| Chemical | |
Reg. No./Substance:
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0/Benzazepines; 0/Hypnotics and Sedatives; 0/Receptors, Dopamine D1; 0/Receptors, Dopamine D2; 0/Salicylamides; 52-86-8/Haloperidol; 84225-95-6/Raclopride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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