Document Detail


Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma.
MedLine Citation:
PMID:  22552850     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic Traumatic Encephalopathy (CTE) is a neurodegenerative disease thought to be caused, at least in part, by repetitive brain trauma, including concussive and subconcussive injuries. It is thought to result in executive dysfunction, memory impairment, depression and suicidality, apathy, poor impulse control, and eventually dementia. Beyond repetitive brain trauma, the risk factors for CTE remain unknown. CTE is neuropathologically characterized by aggregation and accumulation of hyperphosphorylated tau and TDP-43. Recent postmortem findings indicate that CTE may affect a broader population than was initially conceptualized, particularly contact sport athletes and those with a history of military combat. Given the large population that could potentially be affected, CTE may represent an important issue in public health. Although there has been greater public awareness brought to the condition in recent years, there are still many research questions that remain. Thus far, CTE can only be diagnosed post-mortem. Current research efforts are focused on the creation of clinical diagnostic criteria, finding objective biomarkers for CTE, and understanding the additional risk factors and underlying mechanism that causes the disease. This review examines research to date and suggests future directions worthy of exploration.
Authors:
Christine M Baugh; Julie M Stamm; David O Riley; Brandon E Gavett; Martha E Shenton; Alexander Lin; Christopher J Nowinski; Robert C Cantu; Ann C McKee; Robert A Stern
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Brain imaging and behavior     Volume:  6     ISSN:  1931-7565     ISO Abbreviation:  Brain Imaging Behav     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-07-03     Completed Date:  2012-11-28     Revised Date:  2013-05-24    
Medline Journal Info:
Nlm Unique ID:  101300405     Medline TA:  Brain Imaging Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  244-54     Citation Subset:  IM    
Affiliation:
Center for the Study of Traumatic Encephalopathy, Boston University School of Medicine, MA 02118, USA.
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MeSH Terms
Descriptor/Qualifier:
Brain Concussion / complications*,  diagnosis*
Brain Injury, Chronic / diagnosis*,  etiology*
Humans
Neuroimaging / methods*
Grant Support
ID/Acronym/Agency:
P30 AG013846/AG/NIA NIH HHS; P30 AG13846/AG/NIA NIH HHS; R01 NS078337/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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