Document Detail


Chronic training increases blood oxidative damage but promotes health in elderly men.
MedLine Citation:
PMID:  22215375     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of the present study was to investigate a large panel of oxidative stress biomarkers in long-term trained elderly men to analyse the effects of chronic training on an aged population. We collected blood samples from two groups of male volunteers older than 65 years who maintain a measure of functional independence: one group of sedentary subjects without a history of regular physical activity and the other of subjects who have sustained training, starting during middle age (mean training time=49 ± 8 years). We studied morbidity and polypharmacy, as well as haematological parameters including red cell count, haemoglobin concentration, haematocrit, mean corpuscular volume, red cell distribution width and several oxidative biomarkers including protein carbonyl content and lipid peroxidation in plasma and erythrocytes, red blood cell H2O2-induced haemolysis test, plasma total antioxidant activity and the main antioxidant enzymes of erythrocytes: superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase. After adjusting for confounding factors, we observed an increase in all oxidative damage biomarkers in the plasma and erythrocytes of the long-term exercise group. However, we reported a decrease in the number of diseases per subject with statistical differences nearly significant (p=0.061), reduced intake of medications per subject and lower levels of red cell distribution width in the chronic exercise group. These results indicate that chronic exercise from middle age to old age increases oxidative damage; however, chronic exercise appears to be an effective strategy to attenuate the age-related decline in the elderly.
Authors:
David de Gonzalo-Calvo; Benjamín Fernández-García; Beatriz de Luxán-Delgado; Susana Rodríguez-González; Marina García-Macia; Francisco Manuel Suárez; Juan José Solano; María Josefa Rodríguez-Colunga; Ana Coto-Montes
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2012-01-04
Journal Detail:
Title:  Age (Dordrecht, Netherlands)     Volume:  35     ISSN:  1574-4647     ISO Abbreviation:  Age (Dordr)     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-11     Completed Date:  2013-09-19     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  101250497     Medline TA:  Age (Dordr)     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  407-17     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aging / blood
Analysis of Variance
Antioxidants / metabolism*
Biological Markers / blood*
Catalase / blood
Erythrocytes / enzymology
Exercise / physiology*
Glutathione Peroxidase / blood
Glutathione Reductase / blood
Glutathione Transferase / blood
Hematologic Tests
Humans
Lipid Peroxidation
Male
Oxidative Stress / physiology*
Protein Carbonylation
Sedentary Lifestyle
Spain
Statistics, Nonparametric
Superoxide Dismutase / blood
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 1.8.1.7/Glutathione Reductase; EC 2.5.1.18/Glutathione Transferase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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