| Chronic toxicity of rare-earth elements on human beings: implications of blood biochemical indices in REE-high regions, South Jiangxi. | |
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MedLine Citation:
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PMID: 10949964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blood analyses for rare-earth element (REE)-high background regions in South Jiangxi show that the population averages of many of the biochemical indices deviate markedly from normal values in the normal region. These deviations are thought to be caused by prolonged intake of REE through food chains in view of that the toxicity of other harmful metals such as Pb and Cd can be neglected because of their insignificant amounts in the environment. In comparison with the normal region, blood biochemical indices abnormal in the REE-high regions are manifested as low total serum protein (TSP), albumin, beta-globulin, glutamic pyruvic transitanase, serium triglycerides, and immunoglobulin, but high cholesterol. These deviations may be related to the REE concentration and composition of food chains, and are sex dependent. Certain blood indices (such as TSP) of different age groups in the LREE-high region indicate that the influence of REE on males is a one-way irreversible process, whereas females show a strong ability of restoration. |
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Authors:
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H Zhang; J Feng; W Zhu; C Liu; S Xu; P Shao; D Wu; W Yang; J Gu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological trace element research Volume: 73 ISSN: 0163-4984 ISO Abbreviation: Biol Trace Elem Res Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-11-20 Completed Date: 2000-12-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7911509 Medline TA: Biol Trace Elem Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-17 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alanine Transaminase / blood Albumins / metabolism Cadmium / toxicity China Cholesterol / blood Female Food Contamination Globins / metabolism Humans Immunoglobulins / blood Lead / toxicity Male Metals, Heavy / toxicity* Middle Aged Models, Statistical Proteins / metabolism Sex Factors Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Immunoglobulins; 0/Metals, Heavy; 0/Proteins; 0/Triglycerides; 57-88-5/Cholesterol; 7439-92-1/Lead; 7440-43-9/Cadmium; 9004-22-2/Globins; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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