Document Detail


Chronic toxicity of rare-earth elements on human beings: implications of blood biochemical indices in REE-high regions, South Jiangxi.
MedLine Citation:
PMID:  10949964     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Blood analyses for rare-earth element (REE)-high background regions in South Jiangxi show that the population averages of many of the biochemical indices deviate markedly from normal values in the normal region. These deviations are thought to be caused by prolonged intake of REE through food chains in view of that the toxicity of other harmful metals such as Pb and Cd can be neglected because of their insignificant amounts in the environment. In comparison with the normal region, blood biochemical indices abnormal in the REE-high regions are manifested as low total serum protein (TSP), albumin, beta-globulin, glutamic pyruvic transitanase, serium triglycerides, and immunoglobulin, but high cholesterol. These deviations may be related to the REE concentration and composition of food chains, and are sex dependent. Certain blood indices (such as TSP) of different age groups in the LREE-high region indicate that the influence of REE on males is a one-way irreversible process, whereas females show a strong ability of restoration.
Authors:
H Zhang; J Feng; W Zhu; C Liu; S Xu; P Shao; D Wu; W Yang; J Gu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological trace element research     Volume:  73     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-11-20     Completed Date:  2000-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-17     Citation Subset:  IM    
Affiliation:
State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alanine Transaminase / blood
Albumins / metabolism
Cadmium / toxicity
China
Cholesterol / blood
Female
Food Contamination
Globins / metabolism
Humans
Immunoglobulins / blood
Lead / toxicity
Male
Metals, Heavy / toxicity*
Middle Aged
Models, Statistical
Proteins / metabolism
Sex Factors
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Albumins; 0/Immunoglobulins; 0/Metals, Heavy; 0/Proteins; 0/Triglycerides; 57-88-5/Cholesterol; 7439-92-1/Lead; 7440-43-9/Cadmium; 9004-22-2/Globins; EC 2.6.1.2/Alanine Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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