| Chronic toxicity and oncogenicity bioassay of inhaled toluene in Fischer-344 rats. | |
| | |
MedLine Citation:
|
PMID: 6628894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The chronic toxicity and oncogenicity of inhaled toluene were assessed in Fischer-344 rats. One hundred and twenty animals of each sex were exposed for 6 hours/day, 5 days/week, for up to 24 months at concentrations of toluene in air of 0, 30, 100, or 300 ppm. The calculated time-weighted average concentrations for the 24 months of exposure were 0.0, 30.1, 99.7, and 299.0 ppm, respectively. Interim sacrifices on randomly selected animals were conducted after 6, 12 and 18 months of exposure. All surviving rats were sacrificed at 24 months. A large battery of tissues and organs from all animals in the control and 300 ppm toluene group were examined for histopathology. All animals were examined for clinical changes throughout the course of the study and selected animals were used to determine ophthalmologic, hematologic, clinical blood chemistry or urinalysis effects. There were 140 unscheduled deaths over the 2-years study. Gross pathologic examination of rats dying during the course of the study, or that were sacrificed as scheduled, did not reveal any lesions attributable to toluene exposure. Histologically, a variety of proliferative, degenerative and inflammatory lesions were observed in the control and 300 ppm toluene-exposed group. These lesions were considered unrelated to toluene exposure. The results provide no evidence that toluene causes chronic toxicity or oncogenicity in Fischer-344 rats at these concentrations. |
| | |
Authors:
|
J E Gibson; J F Hardisty |
Related Documents
:
|
1585374 - Alpha-naphthyl butyrate carboxylesterase activity in human and rat nasal tissue. 7889854 - Molecular dosimetry of 2,4-difluoroaniline in humans and rats by determination of hemog... 2731664 - Chronic morpholine exposure of rats. 12122564 - 4-week inhalation toxicity study with a mixture of dichloroethylene and perfluorobutyle... 6180524 - Effect of a single oral dose of endosulfan on intestinal uptake of nutrients and on bru... 8420624 - Age-dependent change in the inhibitory effect of an adenosine agonist on hippocampal ac... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Fundamental and applied toxicology : official journal of the Society of Toxicology Volume: 3 ISSN: 0272-0590 ISO Abbreviation: Fundam Appl Toxicol Publication Date: 1983 Jul-Aug |
Date Detail:
|
Created Date: 1983-12-20 Completed Date: 1983-12-20 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8200838 Medline TA: Fundam Appl Toxicol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 315-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Weight / drug effects Carcinogens* Eye Diseases / chemically induced Female Male Rats Rats, Inbred F344 Toluene / blood, toxicity*, urine |
| Chemical | |
Reg. No./Substance:
|
0/Carcinogens; 108-88-3/Toluene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The metabolism of arsenite and arsenate by the rat.
Next Document: Quantitative risk assessment: state-of-the-art for carcinogenesis.