Document Detail

Chronic toxic neuropathy after organophosphorus poisoning in quails (Coturnix coturnix japponica).
MedLine Citation:
PMID:  16541607     Owner:  NLM     Status:  MEDLINE    
Peripheral neuropathy was induced by the long-term administration of organo-phosphorus compounds (phtalimid/phosmet) in quails (Coturnix coturnix japponica). After 4 weeks, the first symptoms of organophosphorus (OPC) poisoning (apathy, diarrhea) were present. During the second month of a daily administration of the toxic substance using the probe, an apparent clinical autonomic and peripheral neuropathy with ataxia had developed. Toxic disturbance of the nervous system was confirmed by the examination of spinal and cortical somatosensory evoked potentials (SEP) after tibial nerve stimulation. The prolongation of the peripheral conduction time (wave P6 and N9 represent the response from the ischiadic nerve and the entry of the stimulus to spinal cord, respectively) confirmed a peripheral nerve lesion. We suggest that these clinical and electrophysiological changes, displayed by the disturbed nervous system, are caused by either slowing or stoppage of the axonal flow, transport of proteins and other substances, as well as by axon demyelination (Tab. 1, Fig. 1, Ref. 22).
P Varsik; D Buranova; M Kondas; P Kucera; Z Goldenberg; V Pokorna
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bratislavské lekárske listy     Volume:  106     ISSN:  0006-9248     ISO Abbreviation:  Bratisl Lek Listy     Publication Date:  2005  
Date Detail:
Created Date:  2006-03-17     Completed Date:  2006-05-10     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0065324     Medline TA:  Bratisl Lek Listy     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  293-6     Citation Subset:  IM    
1st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
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MeSH Terms
Chronic Disease
Evoked Potentials, Somatosensory / drug effects
Insecticides / toxicity*
Peripheral Nervous System Diseases / chemically induced*
Phosmet / toxicity*
Reg. No./Substance:
0/Insecticides; 732-11-6/Phosmet

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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