Document Detail

Chronic tachygastrial electrical stimulation reduces food intake in dogs.
MedLine Citation:
PMID:  17299105     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Tachygastria is known to be associated with gastric hypomotility. This study investigated the effect of tachygastrial electrical stimulation (TES) on food intake and its effects on gastric motility. RESEARCH METHODS AND PROCEDURES: Five experiments were performed to study the effects of TES on gastric slow waves, gastric tone, accommodation, and antral contractions, gastric emptying, acute food intake, and chronic food intake in dogs. RESULTS: TES at tachygastrial frequencies induced tachygastria and reduced normal slow waves. TES significantly reduced gastric tone or induced gastric distention, impaired gastric accommodation, and inhibited antral contractions. TES significantly delayed gastric emptying. Acute TES reduced food intake but did not induce any noticeable symptoms. Chronic TES resulted in a 20% reduction in food intake, and the effect of TES was found to be related to specific parameters. DISCUSSION: TES at the distal antrum results in a significant reduction in food intake in dogs, and this inhibitory effect is probably attributed to TES-induced reduction in proximal gastric tone, gastric accommodation, antral contractility, and gastric emptying. These data suggest a therapeutic potential of the specific method of TES for obesity.
Jing Zhang; Xiaohong Xu; Jiande D Z Chen
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  15     ISSN:  1930-7381     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-14     Completed Date:  2007-04-26     Revised Date:  2008-01-21    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  330-9     Citation Subset:  IM    
Veterans Research Foundation, VA Medical Center, Oklahoma City, Oklahoma, USA.
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MeSH Terms
Electric Stimulation
Electric Stimulation Therapy / methods*
Gastric Emptying
Models, Biological
Stomach / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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