Document Detail


Chronic swimming reverses cardiac dysfunction and myosin abnormalities in hypertensive rats.
MedLine Citation:
PMID:  2939053     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to determine whether a chronic swimming program could reverse the decreased cardiac function and altered myosin biochemistry found in hearts of rats with established renal hypertension. Ten wk after the onset of hypertension [midpoint (m)], hearts from normotensive controls (C) and hypertensives (H) were studied in an isolated working heart apparatus, and myosin biochemistry was analyzed. Half of the control and hypertensive animals were then subjected to a 10-wk swimming program (Sw) and their hearts were compared with those from age-matched sedentary rats. Body weight was no different at the midpoint of the study between Cm and Hm or at the end point (e) of the study among Ce, Swe, He, or H-Swe. Swimming had no effect on blood pressure in either normotensive or hypertensive rats. Dry heart weight was increased by 46% in Hm compared with Cm and by 36% in He, 21% in Swe, and 61% in H-Swe when compared with Ce. Hypertension was associated in both the mid- and end-point studies, with decreases in coronary flow, stroke work (both per gram left ventricle), ejection fraction, and midwall fractional shortening. In addition, actin-activated myosin adenosinetriphosphatase (ATPase) activity was decreased in Hm and He associated with an increase in the content of the V3 myosin isoenzyme. Although the coronary deficit was not corrected in H-Swe, stroke work, ejection fraction, and fractional midwall shortening were normalized compared with control hearts. Myosin ATPase activity and the myosin isoenzyme distribution were similarly restored in H-Swe.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
T F Schaible; A Malhotra; G J Ciambrone; J Scheuer
Related Documents :
7428673 - The sustained antihypertensive effect of chronic cerebroventricular infusion of angiote...
16414773 - Enicostema littorale: a new source of swertiamarin.
19904303 - Sensitivity enhancement of fiber loop cavity ring-down pressure sensor.
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  60     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-06-09     Completed Date:  1986-06-09     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1435-41     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphatases / metabolism
Animals
Cardiomegaly / etiology
Coronary Circulation
Female
Heart / physiopathology*
Hypertension, Renovascular / complications,  physiopathology,  therapy*
Myosins / metabolism*
Physical Education and Training
Physical Exertion*
Rats
Rats, Inbred Strains
Swimming
Grant Support
ID/Acronym/Agency:
HL-01424/HL/NHLBI NIH HHS; HL-15498/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.4.1/Myosins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Correlation between histochemistry and muscle activity of jaw muscles in cats.
Next Document:  Effect of chloramphenicol and ethidium bromide on the level of ornithine carbamoyltransferase in Neu...