Document Detail

Chronic suppression of testicular function by constant infusion of gonadotropin-releasing hormone agonist and testosterone supplementation in the bonnet monkey (Macaca radiata).
MedLine Citation:
PMID:  1740216     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the efficacy of long-term buserelin acetate infusion to desensitize pituitary and block testicular function in adult male monkeys (Macaca radiata). ANIMALS: Proven fertile male monkeys exhibiting normal testicular function. PROTOCOL: Each of the control (n = 5) and experimental monkeys (n = 10) received a fresh miniosmotic pump every 21 days, whereas pumps in controls delivered vehicle of experimentals released 50 micrograms buserelin acetate every 24 hours. On day 170 (renewed every 60 days) a silastic capsule containing crystalline testosterone (T) was implanted in the experimental monkeys. At the end of 3 years, treatment was stopped, and recovery of testicular function and fertility monitored. RESULTS: (1) Treatment resulted in marked reduction of nocturnal but not basal serum T; (2) the pituitary remained desensitized to buserelin acetate throughout the 3-year period; (3) animals were largely azoospermic with occasional oligospermia exhibited by two monkeys; and (4) withdrawal of treatment restored testicular function, with 70% of animals regaining fertility. CONCLUSION: Long-term infertility (but restorable) can be induced in male monkeys by constant infusion of buserelin acetate and T.
N Ravindranath; V Ramesh; H N Krishnamurthy; A J Rao; R N Moudgal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  57     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-03-26     Completed Date:  1992-03-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  671-6     Citation Subset:  IM    
Indian Institute of Science, Bangalore.
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MeSH Terms
Body Weight / drug effects
Delayed-Action Preparations
Drug Implants
Gonadotropin-Releasing Hormone / administration & dosage,  analogs & derivatives*,  pharmacology
Infusions, Intravenous
Macaca radiata
Organ Size / drug effects
Reference Values
Sperm Count / drug effects
Testis / drug effects,  physiology*
Testosterone / administration & dosage,  blood,  pharmacology*
Triptorelin* / analogs & derivatives*
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Drug Implants; 33515-09-2/Gonadotropin-Releasing Hormone; 57773-63-4/Triptorelin; 57773-65-6/Tryptal; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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