Document Detail


Chronic stress produces enduring decreases in novel stress-evoked c-fos mRNA expression in discrete brain regions of the rat.
MedLine Citation:
PMID:  20102318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic stress produces numerous adaptations within the hypothalamic-pituitary-adrenal (HPA) axis that persist well after cessation of chronic stress. We previously demonstrated profound attenuation of HPA axis responses to novel environment 4-7 days following chronic stress. The present study tests the hypothesis that this HPA axis hyporesponsivity is associated with reductions in stress-evoked c-fos mRNA expression, a marker of neuronal activation, in discrete brain regions. Adult male Sprague-Dawley rats underwent 1 week of chronic variable stress (CVS), with unhandled rats serving as controls. Independent groups of control and CVS rats were exposed to novel environment at 16 h, 4 days, 7 days, or 30 days after CVS. Marked reductions of c-fos mRNA expression in the CVS group persisted for at least 30 days within the paraventricular nucleus of the hypothalamus, and for at least 1 week in rostroventrolateral septum and lateral hypothalamus. Lower levels of c-fos mRNA expression were observed at 16 h recovery in the ventrolateral medial preoptic area, basolateral amygdala, anterior cingulate cortex, and prelimbic cortex. The results demonstrate long-term alterations in neuronal activation within neurocircuits critical for regulation of physiological and psychological responses to stressors.
Authors:
M M Ostrander; Y M Ulrich-Lai; D C Choi; J N Flak; N M Richtand; J P Herman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Stress (Amsterdam, Netherlands)     Volume:  12     ISSN:  1607-8888     ISO Abbreviation:  Stress     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-09-20     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  9617529     Medline TA:  Stress     Country:  England    
Other Details:
Languages:  eng     Pagination:  469-77     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / blood
Animals
Corticosterone / blood
Hypothalamo-Hypophyseal System / physiology*
Male
Paraventricular Hypothalamic Nucleus / metabolism*
Pituitary-Adrenal System / physiology*
Proto-Oncogene Proteins c-fos / biosynthesis*
RNA, Messenger / metabolism
Rats
Rats, Sprague-Dawley
Stress, Psychological / physiopathology*
Grant Support
ID/Acronym/Agency:
AG012962/AG/NIA NIH HHS; DA016466/DA/NIDA NIH HHS; DA016778/DA/NIDA NIH HHS; DK067820/DK/NIDDK NIH HHS; F32 DK067820/DK/NIDDK NIH HHS; F32 DK067820-02/DK/NIDDK NIH HHS; MH049698/MH/NIMH NIH HHS; MH069725/MH/NIMH NIH HHS; R01 MH049698/MH/NIMH NIH HHS; R01 MH069725/MH/NIMH NIH HHS; R01 MH069860/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 0/RNA, Messenger; 9002-60-2/Adrenocorticotropic Hormone; W980KJ009P/Corticosterone
Comments/Corrections

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