| Chronic static magnetic field exposure alters microvessel enlargement resulting from surgical intervention. | |
| | |
MedLine Citation:
|
PMID: 17478604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Magnetic field therapy has recently become a widely used complementary/alternative medicine for the treatment of vascular, as well as other musculoskeletal pathologies, including soft tissue injuries. Recent studies in our laboratory and others have suggested that acute static magnetic field (SMF) exposure can have a modulatory influence on the microvasculature, acting to normalize vascular function; however, the effect of chronic SMF exposure has not been investigated. This study aimed to measure, for the first time, the adaptive microvascular response to a chronic 7-day continuous magnetic field exposure. Murine dorsal skinfold chambers were applied on day 0, and neodymium static magnets (or size and weight-matched shams) were affixed to the chambers at day 0, where they remained until day 7. Separate analysis of arteriolar and venular diameters revealed that chronic SMF application significantly abrogated the luminal diameter expansion observed in sham-treated networks. Magnet-treated venular diameters were significantly reduced at day 4 and day 7 (34.3 and 54.4%, respectively) compared with sham-treated vessels. Arteriolar diameters were also significantly reduced by magnet treatment at day 7 (50%), but not significantly at day 4 (31.6%), although the same trend was evident. Venular functional length density was also significantly reduced (60%) by chronic field application. These results suggest that chronic SMF exposure can alter the adaptive microvascular remodeling response to mechanical injury, thus supporting the further study of chronic application of SMFs for the treatment of vascular pathologies involving the dysregulation of microvascular structure. |
| | |
Authors:
|
Cassandra E Morris; Thomas C Skalak |
Related Documents
:
|
10991384 - Magnetic field dependence of ultracold inelastic collisions near a feshbach resonance 10050944 - Low-field magnetic resonance imaging of the pelvis in patients with anal dynamic gracil... 21097054 - Poly(n-isopropylacrylamide) beads synthesis with nanoparticles embedded for the impleme... 16230904 - Comparison of magnetic properties of mri contrast media solutions at different magnetic... 14610624 - Comparison of chlorzoxazone one-sample methods to estimate cyp2e1 activity in humans. 22511054 - Clinics in diagnostic imaging (139). displaced medial meniscus bucket-handle tear. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2007-05-03 |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 103 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2007 Aug |
Date Detail:
|
Created Date: 2007-08-01 Completed Date: 2007-09-20 Revised Date: 2007-12-03 |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: 629-36 Citation Subset: IM |
Affiliation:
|
Dept. of Biomedical Engineering, Univ. of Virginia Health Sciences Center, Charlottesville, VA 22908, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arterioles / anatomy & histology*, physiology, surgery Magnetics* Male Mice Mice, Inbred C57BL Microcirculation / physiology Regional Blood Flow / physiology Skin / blood supply Vasodilation / physiology Venules / anatomy & histology*, physiology, surgery |
| Grant Support | |
ID/Acronym/Agency:
|
AT-00582/AT/NCCAM NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Doping dose of salbutamol and exercise training: impact on the skeleton of ovariectomized rats.
Next Document: Viscerosomatic interaction induced by myocardial ischemia in conscious dogs.