Document Detail


Chronic spontaneous urticaria: epidemiological characteristics focusing on the histocompatibility profile and presence of antibodies.
MedLine Citation:
PMID:  23004006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Understanding the etiopathogenesis of chronic spontaneous urticaria (CSU) remains a challenge. The clinical and laboratory characteristics relating to its histocompatibility profile and autoimmunity are constant research topics.
OBJECTIVES: To analyze the clinical and laboratory characteristics of patients with CSU by means of a cross-sectional study, focusing on the histocompatibility profile, presence of antinuclear antibodies (ANA) and presence of antithyroperoxidase antibodies (anti-TPO).
MATERIALS & METHODS: Sixty-seven adults with CSU were analyzed. The autologous serum skin test (ASST), ANA and anti-TPO were performed in all cases and MHC classes I and II (loci A, B and DR) were evaluated in 49 patients.
RESULTS: The factors that worsened urticaria included use of non-steroid anti-inflammatory drugs, emotional stress and physical stimuli, reported by 27%, 16% and 15% of these patients, respectively. The ASST test was positive in 49 patients (73%) and anti-TPO and ANA were present in 15 (22.4%) and 7 (10.5%), respectively. The OR (with 95% CI) for the association between ANA and anti-TPO was 5.94 (1.16-30.42), and thus statistically significant. There was a favorable association (with statistical significance) between HLA B*50 and patients with CSU, with OR (95% CI) of 2.96 (1.17- 7.48).
CONCLUSION: A significant favorable association was found between these patients and HLA B*50, and between the presence of anti-TPO and ANA. The greater prevalence of HLA B*50 in these patients and the association between ANA and anti-TPO reinforce the possibility that an immunogenic mechanism may be the triggering factor for CSU.
Authors:
Zamir Calamita; Andrea Bronhara Pelá Calamita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Inflammation & allergy drug targets     Volume:  12     ISSN:  2212-4055     ISO Abbreviation:  Inflamm Allergy Drug Targets     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-27     Completed Date:  2013-08-23     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101266886     Medline TA:  Inflamm Allergy Drug Targets     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  8-11     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Inflammatory Agents, Non-Steroidal
Antibodies, Antinuclear / blood
Autoantigens / immunology
Brazil
Chronic Disease
Cross-Sectional Studies
Female
HLA-B Antigens / genetics,  immunology,  metabolism*
Histocompatibility / genetics
Histocompatibility Testing
Humans
Iodide Peroxidase / immunology
Iron-Binding Proteins / immunology
Male
Prevalence
Risk Factors
Skin Tests
Stress, Psychological
Urticaria / epidemiology*,  genetics,  immunology*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antibodies, Antinuclear; 0/Autoantigens; 0/HLA-B Antigens; 0/Iron-Binding Proteins; EC 1.11.1.7/TPO protein, human; EC 1.11.1.8/Iodide Peroxidase

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