Document Detail

Chronic smoking and brain gray matter changes: evidence from meta-analysis of voxel-based morphometry studies.
MedLine Citation:
PMID:  23207549     Owner:  NLM     Status:  Publisher    
Structural neuroimaging studies on chronic smokers using voxel-based morphometry (VBM) had provided cumulative evidence of gray matter (GM) changes relative to nonsmokers. However, not all the studies reported entirely consistent findings. Here, we aimed at identifying consistent GM anomalies in chronic smokers by performing a meta-analysis, and a systematic search of VBM studies on chronic smokers and nonsmokers published in PubMed and Embase database from 2000 to April 2012. Meta-analysis was performed using a newly improved voxel-based meta-analytic tool, namely effect size signed differential mapping, to quantitatively explore the GM abnormalities between chronic smokers and nonsmokers. A total of 7 eligible VBM studies involving 213 chronic smokers and 205 nonsmokers met the inclusion criteria. A considerable regional GM volume decrease was detected in the anterior cingulate cortex (ACC) (BA 24) extending to BA32 in chronic smokers. The findings remain largely unchanged in the entire brain jackknife sensitivity analyses. The results of the present meta-analysis provide evidence of GM changes in ACC in chronic smokers which may be an important potential therapeutic neuro-target for nicotine dependence.
Pinglei Pan; Haicun Shi; Jianguo Zhong; Peirong Xiao; Yuan Shen; Lijuan Wu; Yuanying Song; Guixiang He
Related Documents :
11199269 - Alcohol, the brain, and behavior. mechanisms of addiction.
24115249 - Matrix metalloprotease activity shapes the magnitude of epsps and spike plasticity with...
14597299 - Right parietal lesions, unilateral spatial neglect, and the egocentric frame of reference.
25100989 - Acute human brain responses to intracortical microelectrode arrays: challenges and futu...
23381349 - Connectivity of the amygdala, piriform, and orbitofrontal cortex during olfactory stimu...
21316419 - Is somatosensory excitability more affected by the perspective or modality content of m...
23476809 - Breaking it down: the ubiquitin proteasome system in neuronal morphogenesis.
21958379 - Characterization of the axon initial segment (ais) of motor neurons and identification ...
8843089 - Vaginocervical stimulation suppresses the expression of c-fos induced by mating in thor...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-4
Journal Detail:
Title:  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology     Volume:  -     ISSN:  1590-3478     ISO Abbreviation:  Neurol. Sci.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959175     Medline TA:  Neurol Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Neurology, Yancheng Third People's Hospital (The Affiliated Yancheng Hospital of Southeast University Medical College), Yancheng, 224001, People's Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The expression of Toll-like receptors in murine Müller cells, the glial cells in retina.
Next Document:  Electrophysiological comparison between males and females in HNPP.