Document Detail

Chronic sialadenitis. An immunocytochemical study in humans.
MedLine Citation:
PMID:  2446419     Owner:  NLM     Status:  MEDLINE    
The cellular changes in salivary gland parenchyma with chronic inflammation were studied immunocytochemically with a panel of antibodies. Myoepithelial cells were labelled with antimyosin, duct cells with a polyclonal anti-callus prekeratin, a monoclonal anti-keratin CAM 5.2 and a monoclonal anti-keratin 7 (RPN 1162), and a subpopulation of basal duct cells with a monoclonal anti-keratin 16a. The wide range of changes observed were similar to those described following experimental duct ligation. One of the most striking features was the survival of myoepithelial cells surrounding persisting acini and ductal structures. Most of these ductal structures appeared to be either surviving intercalated ducts or were altered acinar cells. There was no evidence of myoepithelial or ductal hyperplasia. The 16a positive basally located duct cells which are conspicuous in normal glands, pleomorphic adenomas and in the epithelial islands in lymphoepithelial lesions (Palmer et al. 1985; 1986) were virtually absent, except in one specimen with mild inflammatory changes. If this cell type represents a reserve cell, then loss of it may preclude recovery of the remaining parenchyma following resolution of inflammation.
R M Palmer; J W Eveson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Virchows Archiv. A, Pathological anatomy and histopathology     Volume:  412     ISSN:  0174-7398     ISO Abbreviation:  Virchows Arch A Pathol Anat Histopathol     Publication Date:  1987  
Date Detail:
Created Date:  1988-01-13     Completed Date:  1988-01-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8302198     Medline TA:  Virchows Arch A Pathol Anat Histopathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  73-8     Citation Subset:  IM    
United Medical School, Guy's Hospital, London, UK.
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MeSH Terms
Antibodies, Monoclonal / analysis
Cell Differentiation
Cell Survival
Chronic Disease
Parotid Gland / metabolism,  pathology
Parotitis / metabolism,  pathology
Salivary Gland Diseases / metabolism*
Sialadenitis / metabolism*,  pathology
Staining and Labeling / methods
Submandibular Gland / metabolism,  pathology
Reg. No./Substance:
0/Antibodies, Monoclonal

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