| Chronic rhinosinusitis with nasal polyps: elevated serum immunoglobulin E is associated with Staphylococcus aureus on culture. | |
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MedLine Citation:
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PMID: 22144053 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Recent data has implicated Staphylococcus aureus (SA) superantigen as a potential disease modifier in patients with chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP). The objective of this work was to compare total serum immunoglobulin E (IgE) and serum eosinophils in patients with CRSwNP and CRS without nasal polyps (CRSsNP) based on culture results of the 3 most commonly isolated bacteria. METHODS: Retrospective review at a tertiary rhinology referral center of patients with CRS over a 4-year period. RESULTS: Bacterial cultures and immunologic data were obtained from 62 patients with CRSwNP and 34 patients with CRSsNP. SA was the most prevalent bacteria in the CRSwNP group, isolated in 19 patients (31%). Patients with elevated total serum IgE (>114 IU/mL) were more likely to have SA on culture (p = 0.04) in this population. The percent serum eosinophil levels in the SA+ group compared with the SA- group was not significant (6.0 vs 5.1, p = 0.17). Lund-Mackay computed tomography (CT) scores, but not Sino-Nasal Outcome Test 20 (SNOT-20) scores were significantly higher in the SA+ vs SA- group (p = 0.03) in patients with CRSwNP. The CRSsNP group demonstrated no difference in IgE or serum eosinophils between different bacterial groups. CONCLUSION: Our findings suggest that there is an association between SA sinonasal presence and elevated total serum IgE in patients with CRSwNP. In addition, SA+ patients had higher Lund-Mackay CT scores, indicating a higher objective burden of disease in this group of patients. © 2011 ARS-AAOA, LLC. |
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Authors:
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David W Clark; Ashley Wenaas; Martin J Citardi; Amber Luong; Samer Fakhri |
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Publication Detail:
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Type: Journal Article Date: 2011-07-18 |
Journal Detail:
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Title: International forum of allergy & rhinology Volume: 1 ISSN: 2042-6984 ISO Abbreviation: Int Forum Allergy Rhinol Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101550261 Medline TA: Int Forum Allergy Rhinol Country: United States |
Other Details:
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Languages: eng Pagination: 445-50 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Rhinologic Society-American Academy of Otolaryngic Allergy, LLC. |
Affiliation:
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University of Texas Medical School at Houston, Department of Otorhinolaryngology-Head and Neck Surgery and Texas Sinus Institute, Houston, TX. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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