Document Detail


Chronic rhinonsinusitis and nasal polyposis: the etiopathogenesis revealed?
MedLine Citation:
PMID:  19725391     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nasal polyps represent a severe eosinophilic inflammation of the upper airways which is characterized by poor impact of therapeutic intervention and frequent recurrences. Based on distinct cytokine, mediator and cell profiles, chronic sinonasal disease in Caucasians can be differentiated into several subgroups such as chronic rhinosinusitis without nasal polyps, chronic rhinosinusitis with nasal polyps, and nasal polyps in cystic fibrosis patients,. In Caucasians, nasal polyps showed a Th2 polarisation with high IL-5 concentrations, while chronic rhinosinusitis without polyps was characterized by a Thl polarisation with high levels of IFN-gamma. In the Caucasian nasal polyps we found that significantly more nasal polyp patients are colonized with S. aureus and that colonization increased in patients with concomitant asthma and aspirin sensitivity. Although there was no major difference in the presence of enterotoxin genes in S. aureus strains derived from nasal polyp or control patients, we found an increased immune response to S. aureus enterotoxins in nasal polyps, which resulted in a more pronounced eosinophilic inflammation and higher total IgE production in those polyps affected. We suggest that S. aureus superantigens amplify the inflammation in about 50% of nasal polyps, resulting in a strong Th2 polarisation, eosinophil activation, and an overproduction of IgG4 and IgE. These findings imply new therapeutic approaches apart from the currently used topical and systemic steroid therapy for nasal polyposis. In three double blind placebo controlled studies it was shown that firstly, oral corticosteroids only led to a short term reduction of polyp size. Secondly that a low dose of doxycycline treatment for 20 days had a sustained clinically relevant effect on polyp size for more than 3 months and thirdly we also showed a significant effect on polyp size by selective antagonizing IL-5 with a monoclonal antibody.
Authors:
P Van Cauwenberge; T Van Zele; C Bachert
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Verhandelingen - Koninklijke Academie voor Geneeskunde van België     Volume:  70     ISSN:  0302-6469     ISO Abbreviation:  Verh. K. Acad. Geneeskd. Belg.     Publication Date:  2008  
Date Detail:
Created Date:  2009-09-03     Completed Date:  2009-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413210     Medline TA:  Verh K Acad Geneeskd Belg     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  305-22     Citation Subset:  IM    
Affiliation:
Universiteit Gent - Vakgroep neus-, keel-, en oorheelkunde, Upper airways research laboratory, De Pintelaan 185 - B 9000 Gent.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Monoclonal / therapeutic use
Chronic Disease
Doxycycline / therapeutic use*
Enterotoxins / immunology*
Humans
Immunoglobulin E / biosynthesis
Immunoglobulin G / immunology
Interleukin-5 / antagonists & inhibitors
Nasal Polyps / etiology*,  microbiology,  prevention & control
Sinusitis / etiology*,  microbiology,  prevention & control
Staphylococcus aureus / immunology
Superantigens / immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Enterotoxins; 0/Immunoglobulin G; 0/Interleukin-5; 0/Superantigens; 37341-29-0/Immunoglobulin E; 564-25-0/Doxycycline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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