Document Detail

Chronic rhinocerebral mucormycosis.
MedLine Citation:
PMID:  8849804     Owner:  NLM     Status:  MEDLINE    
Rhinocerebral mucormycosis is a well-described fulminant fungal infection that typically presents acutely in patients with diabetic ketoacidosis or immunosuppression. Chronic presentations of rhinocerebral mucormycosis have also been described. In the chronic infection, the disease course is indolent and slowly progressive, often occurring over weeks to months. The authors report 2 cases of chronic rhinocerebral mucormycosis (CRM) treated at their institution and review 16 other cases reported in the English-language literature. In these cases, the median time from symptom onset to diagnosis was 7 months. The most common presenting features of CRM are ophthalmologic and include ptosis, proptosis, visual loss, and ophthalmoplegia. CRM occurs predominantly in patients with diabetes and ketoacidosis. The incidence of internal carotid artery and cavernous sinus thrombosis is higher in CRM patients than in those with the acute disease, although the overall survival rate for CRM patients is 83%. CRM is clinically distinct from chronic Entomophthorales infection.
W C Harril; M G Stewart; A G Lee; P Cernoch
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The Laryngoscope     Volume:  106     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-12-04     Completed Date:  1996-12-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1292-7     Citation Subset:  IM    
Department of Otolarynology and Communicative Sciences, Baylor College of Medicine, Houston, TX 77030, USA.
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MeSH Terms
Blepharoptosis / microbiology
Brain Diseases / complications,  diagnosis*,  microbiology
Chronic Disease
Diabetes Complications
Eye Infections, Fungal / complications,  diagnosis*,  microbiology
Middle Aged
Mucormycosis / complications,  diagnosis*
Nose Diseases / complications,  microbiology*
Ophthalmoplegia / complications,  microbiology*
Orbital Diseases / complications,  diagnosis,  microbiology

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