| Chronic rhinitis in HTLV-1 carriers: a histopathologic study. | |
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MedLine Citation:
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PMID: 22499368 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The nasal histopathology of HTLV-1 carriers with chronic rhinitis is unknown. OBJECTIVE: To describe the histopathological features of HTLV-1 carriers with chronic rhinitis. MATERIALS AND METHODS: Biopsies of nasal mucosa of ten HTLV-1 carriers with chronic rhinitis (eight patients with allergic rhinitis and two patients with non-allergic rhinitis) were studied using a light microscope. Samples from ten patients with allergic rhinitis not infected with HTLV-1 were used as controls. RESULTS: Subepithelial fibrosis was more pronounced in patients with allergic rhinitis infected with HTLV-1 (p=0.01), while the basement membrane thickness was greater in controls (p=0.03). There was a trend towards less eosinophilia and edema among those infected with HTLV-1, without statistical significance (p=0.2). For the lymphocytic infiltrate, there was no difference between infected and not infected patients with allergic rhinitis (p=1.0). Subepithelial fibrosis associated to moderate or small number of lymphocytes were found in the two HTLV-1 carriers with non-allergic rhinitis. CONCLUSIONS: This study suggests HTLV-1 may modify the histopathology of allergic rhinitis, especially by promoting subepithelial fibrosis, and may be related to chronic non-allergic rhinitis with lymphocytic infiltrate. |
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Authors:
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Fernando P Gaspar Sobrinho; Adelmir Souza-Machado; Alvaro A Cruz; Hélio A Lessa; Eduardo A Ramos |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Brazilian journal of otorhinolaryngology Volume: 78 ISSN: 1808-8686 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101207337 Medline TA: Braz J Otorhinolaryngol Country: - |
Other Details:
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Languages: ENG; POR Pagination: 35-40 Citation Subset: - |
Vernacular Title:
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Rinite crônica em portadores do HTLV-1: estudo histopatológico. |
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