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Chronic restricted access to food leading to undernutrition affects rat neuroendocrine status and olfactory-driven behaviours.
MedLine Citation:
PMID:  22633909     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Previous studies have demonstrated that olfactory-driven behaviors in rats are influenced by short-term caloric restriction, partly through the modulation of olfactory sensitivity by appetite-modulating hormones or peptides such as insulin and leptin. Here, we addressed the issue of a long-term modulation of their neuroendocrine status by evaluating the effect of chronic food restriction in rats following a limitation of the duration of daily food intake to 2h (SF) instead of 8h (LF) on the expression of insulin and leptin system in the olfactory mucosa and bulb and on olfactory behaviors. This restriction resulted in a one-third reduction in the daily food intake and a 25% reduction in the body weight of SF rats when compared to controls, and was accompanied by lower levels of triglycerides, glucose, insulin and leptin in SF rats. Under these conditions, we observed a modulation of olfactory-mediated behaviors regarding food odors. In addition, restriction had a differential effect on the expression of insulin receptors, but not that of leptin receptors, in the olfactory mucosa, whereas no transcriptional change was observed at the upper level of the olfactory bulb. Overall, these data demonstrated that long-term changes in nutritional status modulate olfactory-mediated behaviors. Modulation of insulin system expression in the olfactory mucosa of food restricted rats suggests that this hormone could be part of this process.
Authors:
Karine Badonnel; Marie-Christine Lacroix; Régine Monnerie; Didier Durieux; Monique Caillol; Christine Baly
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-23
Journal Detail:
Title:  Hormones and behavior     Volume:  -     ISSN:  1095-6867     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217764     Medline TA:  Horm Behav     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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