Document Detail

Chronic restraint stress does not sensitize a muscarinic mechanism.
MedLine Citation:
PMID:  2626450     Owner:  NLM     Status:  MEDLINE    
Describing the neurobiological changes which may explain the link between chronic stressors and the epidemiological association of recurrent episodes of depression in patients with unipolar or bipolar illness is a goal of psychiatric research. Disorders of mood may involve hyperactivity of central muscarinic mechanisms. Chronic forced swim stress and footshock produce supersensitivity to a muscarinic agonist. Chronic prolonged restraint is a severe stressor for the rat and activates the hypothalamic-pituitary-adrenal (HPA) axis. This report presents data suggesting that this stressor does not, unlike forced swim stress and footshock, enhance sensitivity to the hypothermic effects of a muscarinic agonist.
D D Flemmer; S C Dilsaver
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  34     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1990-04-03     Completed Date:  1990-04-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  207-8     Citation Subset:  IM; S    
Department of Psychiatry, Ohio State University, Columbus 43210-1228.
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MeSH Terms
Body Temperature / drug effects*
Oxotremorine / pharmacology*
Rats, Inbred Strains
Restraint, Physical
Stress, Physiological / physiopathology*
Grant Support
Reg. No./Substance:

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