Document Detail

Chronic respiratory morbidity after prolonged and premature rupture of the membranes.
MedLine Citation:
PMID:  2400226     Owner:  NLM     Status:  MEDLINE    
Twenty one surviving infants of pregnancies complicated by rupture of the membranes during the second trimester that lasted at least one week have been followed up for a median of 15 months. Five infants (24%) had recurrent respiratory problems (episodes of wheezing and coughing occurring at least once a week) which related significantly to the use of neonatal ventilation and to very preterm delivery. Five of the 18 infants who were born preterm and with birth weights of less than 2500 g had recurrent respiratory symptoms (28%). This compares favourably with an incidence of symptoms of 67% among surviving low birthweight infants born at this hospital after pregnancies not complicated by premature rupture of the membranes. Neither recurrent respiratory symptoms nor admission to hospital for chest related disorders were associated with the timing of onset or duration of rupture of the membranes. We conclude that, among survivors of premature rupture of the membranes, chronic respiratory morbidity would best be prevented by avoiding very preterm delivery, regardless of the duration of the rupture.
P J Thompson; A Greenough; K Nicolaides
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  65     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-10-18     Completed Date:  1990-10-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  878-80     Citation Subset:  AIM; IM    
King's College Hospital, London, Department, Child Health.
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MeSH Terms
Chronic Disease
Cough / etiology
Fetal Membranes, Premature Rupture / complications*
Gestational Age
Infant, Low Birth Weight
Infant, Newborn
Prospective Studies
Respiration Disorders / etiology*
Respiratory Sounds / etiology
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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